BDNF Protein

Catalog No. ABIN7488780

Recombinant BDNF protein expressed in HEK-293 Cells.

Quick Overview for BDNF Protein (ABIN7488780)

Target: BDNF (Brain-Derived Neurotrophic Factor (BDNF))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purity: 95 %

Grade: Premium grade

Product Details

Purpose: Human BDNF / Abrineurin Protein, premium grade

Sequence: His 129 - Arg 247

Characteristics: Human BDNF, premium grade is expressed from human 293 cells (HEK293). It contains AA His 129 - Arg 247 (Accession # P23560-1).

Endotoxin Level: 0.01 EU per μg

Application Details

Comment:

This protein carries no "tag". () The protein has a calculated MW of 13.5 kDa. The protein migrates as 15-17 kDa and 19 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: PBS, pH 7.4

Storage: -20 °C

Storage Comment: -20°C

Target Details

Target: BDNF (Brain-Derived Neurotrophic Factor (BDNF))

Alternative Name: BDNF

Background: Brain-derived neurotrophic factor (BDNF) along with nerve growth factor (NGF), neurotrophin-3 (NT-3), and neurotrophin-4/5 (NT-4/5) are members of the neurotrophin family of trophic factors. The neurotrophins play essential roles in the development, survival, and function of a wide range of neurons in both the peripheral and central nervous systems. The neurotrophins interact with two cell surface receptors, the low affinity P75 receptor and the Trk family of high affinity tyrosine kinase receptors. NGF preferentially binds TrkA, BDNF and NT4/5 bind TrkB, and NT-3 binds TrkC (and TrkA to a lesser extent).

Molecular Weight: 13.5 kDa

Pathways: RTK Signaling, Synaptic Membrane, Feeding Behaviour, Dicarboxylic Acid Transport, Regulation of long-term Neuronal Synaptic Plasticity