PUMA Protein (AA 1-193) (His tag)
Quick Overview for PUMA Protein (AA 1-193) (His tag) (ABIN7504951)
Target
See all PUMA (BBC3) ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- AA 1-193
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Purification tag / Conjugate
- This PUMA protein is labelled with His tag.
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Sequence
- Met1-Asn193
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Characteristics
- A DNA sequence encoding the Human PUMA/BBC3 (Q9BXH1-1) (1M-193N) was expressed with a polyhistidine tag at the N-terminus.
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BCL2 Binding Component 3 (BBC3) (AA 1-193) protein (His tag)
custom-made BBC3 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
BCL2 Binding Component 3 (BBC3) (AA 1-261) protein (His tag)custom-made BBC3 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
BCL2 Binding Component 3 (BBC3) (AA 1-193) protein (His tag)custom-made BBC3 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
BCL2 Binding Component 3 (BBC3) (AA 141-261) protein (His-IF2DI Tag)BBC3 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % by SDS-PAGE gel analyses WB, ELISA
BCL2 Binding Component 3 (BBC3) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)BBC3 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
BCL2 Binding Component 3 (BBC3) (AA 76-170) protein (His tag,Strep II tag)BBC3 Origin: Human Host: Escherichia coli (E. coli) Recombinant ~95 % WB, ELISA, MS
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Comment
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used as Immunogen for (ABIN6999884, ABIN7234184, ABIN7234185 and ABIN7234186)
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
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Lyophilized from sterile PBS, pH 7.4., 5 % trehalose, 5 % mannitol, 0.01 % tween-80.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. -
Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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Expiry Date
- 12 months
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- PUMA (BBC3) (BCL2 Binding Component 3 (BBC3))
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Alternative Name
- PUMA
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Background
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Abbreviation: PUMA,BBC3
Target Synonym: BBC 3,Bbc3,BBC3_HUMAN,BCL 2 binding component 3,Bcl-2-binding component 3,BCL2 binding component 3,JFY 1,JFY-1,JFY1,p53 up regulated modulator of apoptosis,p53 up-regulated modulator of apoptosis,p53 Upregulated Modulator of Apoptosis,PUMA alpha,PUMA/JFY1
Background: Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis . Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53. Regulates ER stress-induced neuronal apoptosis.
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Molecular Weight
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Calculated MW: 20.1 kDa
Observed MW: 20-24 kDa
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UniProt
- Q9BXH1-1
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Pathways
- p53 Signaling, Positive Regulation of Endopeptidase Activity
Target
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