p21 Protein (AA 40-164) (His tag)
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- Target See all p21 (CDKN1A) Proteins
- p21 (CDKN1A) (Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 40-164
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This p21 protein is labelled with His tag.
- Sequence
- Gly 40-Pro 164
- Characteristics
- A DNA sequence encoding the Human P21 protein (P38936) (Gly 40-Pro 164) was expressed with a N-His tag.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
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- Discover our top product CDKN1A Protein
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Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) (AA 2-164) protein (His-IF2DI Tag)
CDKN1A Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) (AA 1-164) protein (GST tag)CDKN1A Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)CDKN1A Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
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Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween80 are added as protectants before lyophilization. - Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- Expiry Date
- 12 months
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- Target
- p21 (CDKN1A) (Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A))
- Alternative Name
- P21 (CDKN1A Products)
- Background
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Abbreviation: P21
Target Synonym: CAP20,CDK-interacting protein 1,CDKI,CDKN1,CDN1A,CIP1,CDKN1A,Cyclin Dependent Kinase Inhibitor 1A,DNA Synthesis Inhibitor,MDA-6,MDA6,Melanoma differentiation-associated protein 6,P21cip1,P21waf,PIC1,SDI1,SLC12A9,WAF1
Background: May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.
- Molecular Weight
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Calculated MW: 13.64 kDa
Observed MW: 18 kDa
- UniProt
- P38936
- Pathways
- p53 Signaling, PI3K-Akt Signaling, Cell Division Cycle, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Mitotic G1-G1/S Phases, DNA Replication, Hepatitis C, Synthesis of DNA, Autophagy
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