PDGF-BB Homodimer (Active) Protein
Quick Overview for PDGF-BB Homodimer (Active) Protein (ABIN7520387)
Target
Protein Type
Biological Activity
Origin
Source
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Purpose
- Recombinant Human PDGF-BB Protein
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Sequence
- SLGSLTIAEP AMIAECKTRT EVFEISRRLI DRTNANFLVW PPCVEVQRCS GCCNNRNVQC RPTQVQLRPV QVRKIEIVRK KPIFKKATVT LEDHLACKCE TVAAARPVT
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Specificity
- Ser82-Thr190
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Sterility
- 0.22 μm filtered
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Endotoxin Level
- < 0.1EU/μg
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Biological Activity Comment
- Measured by its binding ability in a functional ELISA.Immobilized PDGF-BB at 2 μg/mL (100 μL/well) can bind Human PDGFRB with a linear range of 0.1-104.7 ng/mL.
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PDGF-BB Homodimer protein
Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 98 % as determined by reducing SDS-PAGE.
PDGF-BB Homodimer (Active) protein (His tag)Origin: Human Host: Yeast Recombinant > 95 % as determined by reducing SDS-PAGE. Active
PDGF-BB Homodimer (AA 82-190) (Active) proteinOrigin: Human Host: Escherichia coli (E. coli) Recombinant >90 % as determined by reducing (R) and non-reducing (NR) SDS-PAGE. Active
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.
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Concentration
- 0.3 mg/mL
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Buffer
- Lyophilized from a 0.22 μm filtered solution of 20 mM NaAc, pH 4.5.
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Storage
- -20 °C,-80 °C
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Storage Comment
- Store the lyophilized protein at -20°C to -80°C for 12 months.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
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- PDGF-BB Homodimer
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Alternative Name
- PDGF-BB
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Background
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Description: Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionality. Interestingly, this effect exerted by PDGFB was also observed in the presence of DAPT. So PDGFB is able to improve tumor vascularity and allows the anticancer action of DAPT in the tumor.
Name: SIS, SSV, IBGC5, PDGF2, c-sis, PDGF-2,PDGF subunit B,PDGF-BB,PDGFB
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Gene ID
- 5155
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UniProt
- P01127
Target
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