RMI2 Protein (AA 1-149) (His tag)

Catalog No. ABIN7557250

This Recombinant RMI2 protein is produced in HEK-293 Cells.

Quick Overview for RMI2 Protein (AA 1-149) (His tag) (ABIN7557250)

Target: RMI2 (RMI2, RecQ Mediated Genome Instability 2 (RMI2))

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Product Details

Protein Characteristics: AA 1-149

Purification tag / Conjugate: This RMI2 protein is labelled with His tag.

Purpose: Predefined custom protein recombinant Rmi2 Protein expressed in mammalian cells.

Sequence: MAAAASESLS SGGPGAVRLP RLPPLKVLAG QLRRHAEGGP GAWRLSRAAV GRAPLELVAV WMQGTVLAAE GGQARLRDSS GAFSVRGLER VPRGRPCLLP GKYVMVMGVV QACSPEPCLQ AVKMTDLSDN PVHESMWELE VEDLHRNIP Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Predefined custom protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: RMI2 (RMI2, RecQ Mediated Genome Instability 2 (RMI2))

Alternative Name: Rmi2

Background: RecQ-mediated genome instability protein 2,FUNCTION: Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localization, and function of BLM, TOP3A, and complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM. {ECO:0000250|UniProtKB:Q96E14}.

Molecular Weight: 15.8 kDa

UniProt: Q3UPE3

AlphaFold: Q3UPE3

Pathways: DNA Damage Repair