PUMA Protein (AA 1-193) (His tag)
Quick Overview for PUMA Protein (AA 1-193) (His tag) (ABIN7560411)
Target
See all PUMA (BBC3) ProteinsProtein Type
Origin
Source
Purity
Grade
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Protein Characteristics
- AA 1-193
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Purification tag / Conjugate
- This PUMA protein is labelled with His tag.
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Purpose
- Predefined custom protein recombinant Bbc3 Protein expressed in mammalian cells.
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Sequence
- MARARQEGSS PEPVEGLARD SPRPFPLGRL MPSAVSCSLC EPGLPAAPAA PALLPAAYLC APTAPPAVTA ALGGPRWPGG HRSRPRGPRP DGPQPSLSPA QQHLESPVPS APEALAGGPT QAAPGVRVEE EEWAREIGAQ LRRMADDLNA QYERRRQEEQ HRHRPSPWRV MYNLFMGLLP LPRDPGAPEM EPN Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.
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Specificity
- If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.
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Characteristics
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Key Benefits:
- Predefined custom protein - from design to production - by highly experienced protein experts.
- Protein expressed in mammalian cells and purified in one-step affinity chromatography
- The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
- State-of-the-art algorithm used for plasmid design (Gene synthesis).
If you are not interested in a full length protein, please contact us for individual protein fragments.
The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.
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Want other Options for this Protein ?
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Application Notes
- We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- The buffer composition is at the discretion of the manufacturer.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -80 °C
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Storage Comment
- Store at -80°C.
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Expiry Date
- 12 months
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- PUMA (BBC3) (BCL2 Binding Component 3 (BBC3))
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Alternative Name
- Bbc3
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Background
- Bcl-2-binding component 3 (p53 up-regulated modulator of apoptosis),FUNCTION: Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis (By similarity). Promotes partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53, releasing the bound p53/TP53 to induce apoptosis (By similarity). Regulates ER stress-induced neuronal apoptosis (PubMed:21159964, PubMed:22761832). {ECO:0000250|UniProtKB:Q9BXH1, ECO:0000269|PubMed:21159964, ECO:0000269|PubMed:22761832}.
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Molecular Weight
- 20.7 kDa
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UniProt
- Q99ML1
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AlphaFold
- Q99ML1
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Pathways
- p53 Signaling, Positive Regulation of Endopeptidase Activity
Target
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