SOCS6 Protein (AA 1-533) (His tag)

Catalog No. ABIN7561685

This Recombinant SOCS6 protein is expressed in HEK-293 Cells.

Quick Overview for SOCS6 Protein (AA 1-533) (His tag) (ABIN7561685)

Target: SOCS6 (Suppressor of Cytokine Signaling 6 (SOCS6))

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Product Details

Protein Characteristics: AA 1-533

Purification tag / Conjugate: This SOCS6 protein is labelled with His tag.

Purpose: Predefined custom protein recombinant Socs6 Protein expressed in mammalian cells.

Sequence: MKKISLKTFR KSFNLSKSKD ETEFMVVQPQ SLAGDFVKDD SLFGSCYGKD MASCDIGSED EKGKNRSKSE SLMGTLKRRL SAKQKTKGKG GTASTDEDTF SSASAPGGLK DVRAPRPIRS TSLRSHHYSP TPWPLRPTSS EETCIKMEMR VKALVHAASP GPVNGVRKDL RELQPRELRD LQPEPRPESR CSPSSPGDLS LHLEEHVPVV IGLMSQDYLQ YTVPLDDGMC PLEGPRSCCL DTSSPMEVSA VPLPGASGAF SEDDSHVDQD LVVGPEILVD SSVNNLLIGT TGVMLQSPRG GHDDAPPLSP LLPPMQNNPI QRNFSGLSGP DLHMAESVRC HLNFDPNSAP GVARVYDSVQ SSGPMVVTSL TEELKKLAKQ GWYWGPITRW EAEGKLANVP DGSFLVRDSS DDRYLLSLSF RSHGKTLHTR IEHSNGRFSF YEQPDVEGHT SIVDLIEHSI RDSENGAFCY SRSRLPGSAT YPVRLTNPVS RFMQVRSLQY LCRFVIRQYT RIDLIQKLPL PNKMKDYLQE KHY Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Predefined custom protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: SOCS6 (Suppressor of Cytokine Signaling 6 (SOCS6))

Alternative Name: Socs6

Background: Suppressor of cytokine signaling 6 (SOCS-6) (Cytokine-inducible SH2 protein 4) (CIS-4) (Suppressor of cytokine signaling 4) (SOCS-4),FUNCTION: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor (By similarity). {ECO:0000250, ECO:0000269|PubMed:16643902}.

Molecular Weight: 59.1 kDa

UniProt: Q9JLY0

AlphaFold: Q9JLY0

Pathways: JAK-STAT Signaling, Carbohydrate Homeostasis