Hepcidin Protein (AA 59-83) (His-TRX)

Catalog No. ABIN7668892

This Recombinant Hepcidin protein is produced in Escherichia coli (E. coli).

Quick Overview for Hepcidin Protein (AA 59-83) (His-TRX) (ABIN7668892)

Target: Hepcidin (HAMP) (Hepcidin Antimicrobial Peptide (HAMP))

Protein Type: Recombinant

Biological Activity: Inactive

Origin: Mouse

Source: Escherichia coli (E. coli)

Purity: > 95 %

Product Details

Protein Characteristics: AA 59-83

Purification tag / Conjugate: This Hepcidin protein is labelled with His-TRX.

Purpose: Recombinant Mouse Hepcidin/Hepc protein (TRX,His tag)

Sequence: Asp59-Thr83

Sterility: 0.2 μm filtered

Endotoxin Level: < 10 EU/mg of the protein as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Buffer: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % -8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: Hepcidin (HAMP) (Hepcidin Antimicrobial Peptide (HAMP))

Alternative Name: Hepcidin,Hepc

Background: Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes.,HEPC_MOUSE,Hamp,Hamp1,Hepc,Hepc1,Hepcidin

Molecular Weight:

calculated_mw: 22.6 kDa

observed_mw: 25 kDa

UniProt: Q9EQ21

Pathways: Hormone Activity, Transition Metal Ion Homeostasis