Hepcidin Protein (AA 59-83) (His-TRX)
Quick Overview for Hepcidin Protein (AA 59-83) (His-TRX) (ABIN7668892)
Target
See all Hepcidin (HAMP) ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- AA 59-83
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Purification tag / Conjugate
- This Hepcidin protein is labelled with His-TRX.
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Purpose
- Recombinant Mouse Hepcidin/Hepc Protein (TRX,His Tag)
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Sequence
- Asp59-Thr83
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Sterility
- 0.2 μm filtered
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Endotoxin Level
- < 10 EU/mg of the protein as determined by the LAL method
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Biological Activity Comment
- Not validated for activity
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
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Buffer
- Lyophilized from a 0.2 μm filtered solution in PBS with 5 % Trehalose and 5 % Mannitol.
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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Expiry Date
- 12 months
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- Hepcidin (HAMP) (Hepcidin Antimicrobial Peptide (HAMP))
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Alternative Name
- Hepcidin,Hepc
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Background
- HEPC_MOUSE,Hamp,Hamp1,Hepc,Hepc1,Hepcidin,Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes.
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Molecular Weight
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Calculated MW: 22.6 kDa
Observed MW: 25 kDa
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Gene ID
- 84506
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UniProt
- Q9EQ21
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Pathways
- Hormone Activity, Transition Metal Ion Homeostasis
Target
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