c-MET Protein (His tag)

Catalog No. ABIN7794635

Recombinant c-MET protein expressed in HEK-293 Cells.

Quick Overview for c-MET Protein (His tag) (ABIN7794635)

Target: c-MET (MET) (Met Proto-Oncogene (MET))

Protein Type: Recombinant

Origin: Cynomolgus

Source: HEK-293 Cells

Purity: The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.

Product Details

Purification tag / Conjugate: This c-MET protein is labelled with His tag.

Purpose: Recombinant Cynomolgus MET protein with C-terminal 10?His tag

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Target Details

Target: c-MET (MET) (Met Proto-Oncogene (MET))

Alternative Name: MET

Background: DA11, HGFR, AUTS9, RCCP2, c-Met, DFNB97 Background: This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016]

Molecular Weight: Predicted: 103.1 kDa after removal of the signal peptide. The apparent molecular mass of cMET-His is approximately 100-130 kDa due to glycosylation.

NCBI Accession: XP_005550635

Pathways: RTK Signaling, Carbohydrate Homeostasis, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor