M-CSF/CSF1 Protein

Catalog No. ABIN7866449

Recombinant M-CSF/CSF1 protein expressed in Escherichia coli (E. coli).

Quick Overview for M-CSF/CSF1 Protein (ABIN7866449)

Target: M-CSF/CSF1 (CSF1) (Colony Stimulating Factor 1 (Macrophage) (CSF1))

Protein Type: Recombinant

Biological Activity: Active

Origin: Mouse

Source: Escherichia coli (E. coli)

Purity: > 98 % by SDS-PAGE

Product Details

Purpose: Recombinant Mouse M-CSF Protein

Sequence: MKEVSEHCSH MIGNGHLKVL QQLIDSQMET SCQIAFEFVD QEQLDDPVCY LKKAFFLVQD IIDETMRFKD NTPNANATER LQELSNNLNS CFTKDYEEQN KACVRTFHET PLQLLEKIKN FFNETKNLLE KDWNIFTKNC NNSFAKCSSR DVVTKP

Specificity: Chromosomal location:3 F3, 3 51.0 cM

Characteristics: Length (aa):156

Application Details

Application Notes: The biological activity was determined by the induction of proliferation in the NFS 60 cell line.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: water,Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-0.5 mg/mL. Do not vortex. This solution can be stored at 2-8 °C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1 % BSA) and store in working aliquots at -20 °C to -80 °C.

Buffer: PBS

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: The lyophilized protein is stable at room temperature for 1 month and at 4°C for 6 months. Reconstituted working aliquots are stable for 1 week at 2°C to 8°C and for 12 months at -20°C to -80°C.

Expiry Date: 12 months

Target Details

Target: M-CSF/CSF1 (CSF1) (Colony Stimulating Factor 1 (Macrophage) (CSF1))

Alternative Name: M-CSF

Background:

Synonyms: Csf1, op, Csfm, MCSF, C87615

Description: M-CSF is a potent hematopoietic factor produced by a variety of cells including lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts and osteoblasts. It is a key regulator of cellular proliferation, differentiation, and survival of blood monocytes, tissue macrophages and their progenitor cells. M-CSF has been shown to play important roles in modulating dermal thickness, and male and female fertility. M-CSF is clinically used in the treatment of infection, malignancies and atherosclerosis. It facilitates hematopoietic recovery after bone marrow transplantation. The human is reactive in murine systems, but the murine molecule exhibits no activity on human cells. Recombinant murine M-CSF is a 36.4 kDa homodimeric protein containing two 156 amino acid polypeptide subunits.

Molecular Weight: 36.4 kDa

Gene ID: 12977

NCBI Accession: NM_007778, NP_031804

UniProt: P07141

Pathways: RTK Signaling