MERTK Protein (AA 528-999)
Quick Overview for MERTK Protein (AA 528-999) (ABIN7938666)
Target
See all MERTK ProteinsProtein Type
Origin
Source
Application
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Protein Characteristics
- AA 528-999
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Purpose
- Recombinant MER (528-999) protein
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C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 21-505) (Active) protein (mFc Tag)
MERTK Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 19-497) (Active) protein (His tag)MERTK Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 21-120) protein (GST tag)MERTK Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) protein (GST tag,His tag)MERTK Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 92 % as determined by reducing SDS-PAGE.
C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (Active) protein (GST tag,His tag)MERTK Origin: Mouse Host: Baculovirus infected Insect Cells Recombinant > 96 % as determined by SDS-PAGE Active
C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) protein (Fc Tag)MERTK Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE
C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 21-505) protein (Fc Tag)MERTK Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ScA, AM, ADA, IA
C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 21-505) protein (His tag)MERTK Origin: Human Host: Mammalian Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 21-505) protein (His tag)MERTK Origin: Human Host: Mammalian Cells Recombinant The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Recombinant MER (528-999) protein is supplied in 25 mM HEPES-NaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100, and 0.5 mM TCEP.
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Handling Advice
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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Storage
- -80 °C
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Storage Comment
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))
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Alternative Name
- MER
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Background
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Protein Background: MERTK (MER Proto-Oncogene, Tyrosine Kinase) is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. MER regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, MERTK interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. Diseases associated with MERTK include Retinitis Pigmentosa 38 and Retinitis Pigmentosa.
Short Description: Recombinant MER(528-999) protein that includes amino acids 528-999 of human MER protein (accession number NP_006334.2) was expressed in a baculovirus expression system, and contains an N-terminal FLAG tag. The molecular weight of the protein is 54 kDa.
Aliases: MER Proto-Oncogene Tyrosine Kinase, MERTK
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Pathways
- RTK Signaling
Target
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