CDK1 Protein
Quick Overview for CDK1 Protein (ABIN7938734)
Target
See all CDK1 ProteinsProtein Type
Origin
Source
Application
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Purpose
- Recombinant CDK1 protein
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Cyclin-Dependent Kinase 1 (CDK1) (AA 1-297) protein (His tag)
custom-made CDK1 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Cyclin-Dependent Kinase 1 (CDK1) (AA 1-297) protein (His tag)custom-made CDK1 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Cyclin-Dependent Kinase 1 (CDK1) (AA 1-297) protein (GST tag)CDK1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Cyclin-Dependent Kinase 1 (CDK1) protein (GST tag,His tag)CDK1 Origin: Mouse Host: Baculovirus infected Insect Cells Recombinant > 85 % as determined by SDS-PAGE
Cyclin-Dependent Kinase 1 (CDK1) (AA 1-297) protein (His tag)CDK1 Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 95 % SDS
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Recombinant CDK1 protein is supplied in 25 mM HEPES pH 7.5, 300 mM NaCl, 20 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.
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Handling Advice
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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Storage
- -80 °C
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Storage Comment
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- CDK1 (Cyclin-Dependent Kinase 1 (CDK1))
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Alternative Name
- CDK1
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Background
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Protein Background: CDK1 (Cyclin-dependent kinase 1) , also known as CDC2, CDC28A and P34CDC2. CDK1 plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset, promotes G2-M transition via association with multiple interphase cyclins. Associated with its cognate partner cyclin B, is a key enzyme for entry in mitosis and is essential for spindle morphogenesis. CDK1 up-regulates microtubule dynamics when added in cell free Xenopus extracts. CDK1inactivation is necessary for proper anaphase spindle dynamics and for cytokinesis. Large amounts of CDK1 induce the depolymerization of interphase microtubules when injected into mammalian cells and the destabilization of microtubule arrays when added on lysed mammalian cells.
Short Description: Recombinant CDK1 protein was expressed in a baculovirus expression system as the full-length protein (accession number NP_001777.1) with an C-terminal FLAG tag. The molecular weight of CDK1 is 35.79 kDa.
Aliases: CDC2, CDC28A, P34CDC2, Cell Division Protein Kinase 1, CDKN1, P34 Protein Kinase Cyclin-Dependent Kinase 1
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Pathways
- Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Toll-Like Receptors Cascades, Synthesis of DNA
Target
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