CDKN2B Protein
Quick Overview for CDKN2B Protein (ABIN7938742)
Target
See all CDKN2B ProteinsProtein Type
Origin
Source
Application
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Purpose
- Recombinant CDKN2B protein
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Cyclin-Dependent Kinase Inhibitor 2B (p15, Inhibits CDK4) (CDKN2B) (AA 1-130) protein (His tag)
custom-made CDKN2B Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Cyclin-Dependent Kinase Inhibitor 2B (p15, Inhibits CDK4) (CDKN2B) (AA 1-138) protein (His tag)custom-made CDKN2B Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Cyclin-Dependent Kinase Inhibitor 2B (p15, Inhibits CDK4) (CDKN2B) (AA 1-138) protein (GST tag)CDKN2B Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Cyclin-Dependent Kinase Inhibitor 2B (p15, Inhibits CDK4) (CDKN2B) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)CDKN2B Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Recombinant CDKN2B protein is supplied in 25 mM Tris-HCl pH 8.0, 300 mM NaCl, 10 % glycerol and 0.5 mM TCEP.
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Handling Advice
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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Storage
- -80 °C
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Storage Comment
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- CDKN2B (Cyclin-Dependent Kinase Inhibitor 2B (p15, Inhibits CDK4) (CDKN2B))
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Alternative Name
- CDKN2B
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Background
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Protein Background: CDKN2B(Cyclin-dependent kinase 4 inhibitor B,This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclindependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.
Short Description: Recombinant CDKN2B protein that includes full length of human CDKN2B protein (accession number NP_004927.2) was expressed was expressed in E. coli cells with an N-terminal GST tag. The molecular weight of the protein is 41.55 kDa.
Aliases: Cyclin dependent kinase Inhibitor 2B, MTS2, INK4B, CDK4I, TP15, P15, P15 CDK Inhibitor
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Pathways
- Cell Division Cycle, Mitotic G1-G1/S Phases
Target
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