EPH Receptor A2 Protein (EPHA2) (AA 561-976)

Catalog No. ABIN7938796

This Recombinant EPH Receptor A2 protein is expressed in Baculovirus infected Insect Cells.

Quick Overview for EPH Receptor A2 Protein (EPHA2) (AA 561-976) (ABIN7938796)

Target: EPH Receptor A2 (EPHA2)

Protein Type: Recombinant

Origin: Human

Source: Baculovirus infected Insect Cells

Application: Activity Assay (AcA), Screening Assay (ScA), Functional Studies (Func)

Product Details

Protein Characteristics: AA 561-976

Purpose: Recombinant EPHA2 (561-976) protein

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Recombinant EPHA2 (561-976) protein is supplied in 25 mM HEPESNaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100 and 0.5 mM TCEP.

Handling Advice: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Storage: -80 °C

Storage Comment: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Target Details

Target: EPH Receptor A2 (EPHA2)

Alternative Name: EPHA2

Background:

Protein Background: EPHA2(Ephrin type-A receptor 2) is a receptor tyrosine kinase which binds promiscuously membranebound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/ EFNA1 regulates migration, integrin-mediated adhesion, proliferation, and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins.

Short Description: Recombinant EPHA2 (561-976) protein that includes amino acids 561-976 of human EPHA2 protein (accession number NP_004422.2) was expressed in a baculovirus expression system, and contains an N-terminal FLAG tag. The molecular weight of the protein is 48.50 kDa.

Aliases: Ephrin type-A receptor 2, EPH receptor A2, ECK, CTRCT6, EphA2, ARCC2, CTPP1, CTPA

Pathways: RTK Signaling