EPH Receptor A5 Protein (EPHA5) (AA 620-1037)

Catalog No. ABIN7938799

Recombinant EPH Receptor A5 protein expressed in Baculovirus infected Insect Cells.

Quick Overview for EPH Receptor A5 Protein (EPHA5) (AA 620-1037) (ABIN7938799)

Target: EPH Receptor A5 (EPHA5)

Protein Type: Recombinant

Origin: Human

Source: Baculovirus infected Insect Cells

Application: Screening Assay (ScA), Activity Assay (AcA), Functional Studies (Func)

Product Details

Protein Characteristics: AA 620-1037

Purpose: Recombinant EPHA5 (620-1037) protein

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: Recombinant EPHA5 (620-1037) protein is supplied 25 mM HEPES pH 7.5, 300 mM NaCl, 20 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP

Handling Advice: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Storage: -80 °C

Storage Comment: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Target Details

Target: EPH Receptor A5 (EPHA5)

Alternative Name: EPHA5

Background:

Protein Background: EPHA5 (Ephrin type-A receptor 5) is a receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 also plays a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion.

Short Description: Recombinant EPHA5 (620-1037) protein that includes amino acids 620-1037of human EPHA5 protein (accession number NP_004430.4) was expressed in a baculovirus expression system, and contains an N-terminal FLAG tag. The molecular weight of the protein is 48.41 kDa.

Aliases: Ephrin type-A receptor 5, EPHA5, CEK7, EHK1, Hek7, TYRO4

Pathways: RTK Signaling