GAMT Protein
Quick Overview for GAMT Protein (ABIN7938893)
Target
See all GAMT ProteinsProtein Type
Origin
Source
Application
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Purpose
- Recombinant GAMT protein
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Guanidinoacetate N-Methyltransferase (GAMT) (AA 1-236) protein (His tag)
GAMT Origin: Rat Host: Yeast Recombinant > 90 % ELISA
Guanidinoacetate N-Methyltransferase (GAMT) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)GAMT Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Guanidinoacetate N-Methyltransferase (GAMT) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)GAMT Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Recombinant GAMT protein is supplied in 25 mM Tris pH 8.0, 300 mM NaCl, 10 % glycerol, 0.5 mM TCEP.
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Handling Advice
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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Storage
- -80 °C
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Storage Comment
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- GAMT (Guanidinoacetate N-Methyltransferase (GAMT))
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Alternative Name
- GAMT
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Background
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Protein Background: Guanidinoacetate N-methyltransferase is also known as GAMT.The main function of GAMT is Converts guanidinoacetate to creatine, using S-adenosylmethionine as the methyl donor.Guanidinoacetate methyltransferase (GAMT) deficiency is an autosomal recessively inherited disorder of creatine biosynthesis . GAMT enzyme deficiency caused by mutations in the GAMT gene results in the depletion of creatine and accumulation of guanidinoacetate (GAA). Creatine has a buffering and transport function of high-energy phosphates in brain and muscle and is essential for growth cone migration, dendritic and axonal elongation, neurotransmitter release, and cotransmission on gamma amino butyric acid (GABA) postsynaptic receptors in the central nervous system.
Short Description: Recombinant GAMT protein was expressed in E.coli as the full length protein (accession number NP_000147.1) with an N-terminal 6xHis tag. The molecular weight of the protein is 28.11 kDa.
Aliases: Guanidinoacetate N-methyltransferase
Target
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