MBD4 Protein (Methyl-CpG-binding domain)
Quick Overview for MBD4 Protein (Methyl-CpG-binding domain) (ABIN7939275)
Target
See all MBD4 ProteinsProtein Type
Origin
Source
Application
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Protein Characteristics
- Methyl-CpG-binding domain
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Purpose
- Recombinant MBD4-MBD protein
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Methyl-CpG Binding Domain Protein 4 (MBD4) (AA 1-574) protein (GST tag)
MBD4 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Methyl-CpG Binding Domain Protein 4 (MBD4) (AA 68-300) protein (His-IF2DI Tag)MBD4 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. ELISA, WB
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Recombinant MBD4-MBD protein is supplied in 25 mM Tris 8.0, 300 mM NaCl, 20 % glycerol, 0.5 mM TCEP.
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Handling Advice
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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Storage
- -80 °C
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Storage Comment
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- MBD4 (Methyl-CpG Binding Domain Protein 4 (MBD4))
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Alternative Name
- MBD4
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Background
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Protein Background: MBD4 (Methyl-CpG-binding domain protein 4) can mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methylCpG-binding protein.
Short Description: Recombinant MBD4-MBD protein that includes amino acids 71-159 of human MBD4 protein (accession number NP_003916.1) was expressed in E. coli cells with an N-terminal 6xHis tag. The molecular weight of the protein is 12.31 kDa.
Aliases: Methyl-CpG-binding domain protein 4, MED1
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Pathways
- DNA Damage Repair
Target
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