PARG Protein (PARG) (AA 448-976)

Catalog No. ABIN7939407

This Recombinant PARG protein is expressed in Escherichia coli (E. coli).

Quick Overview for PARG Protein (PARG) (AA 448-976) (ABIN7939407)

Target: PARG

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Application: Activity Assay (AcA), Functional Studies (Func), Screening Assay (ScA)

Product Details

Protein Characteristics: AA 448-976

Purpose: Recombinant PARG (448-976) protein

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Recombinant PARG (448-976) protein is supplied in 25 mM Tris 8.0, 300 mM NaCl, 20 % glycerol, 0.5 mM TCEP.

Handling Advice: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Storage: -80 °C

Storage Comment: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Target Details

Target: PARG

Alternative Name: PARG

Background:

Protein Background: PARG (Poly(ADP-ribose) glycohydrolase) catalyzes the hydrolysis of glycosidic bonds of ADP-ribose polymers, producing monomeric ADP-ribose units. Thus, in conjunction with poly(ADP-ribose) polymerase (PARP), PARG activity regulates the extent of in vivo poly(ADP ribosyl)ation. PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers.Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5.

Short Description: Recombinant PARG (448-976) protein that includes amino acids 448-976 of human PARG protein (accession number NP_003622.2) was expressed in E. coli cells with an C-terminal 6xHis tag. The molecular weight of the protein is 62.26 kDa.

Aliases: Poly(ADP-ribose) glycohydrolase, PARG, Mitochondrial Poly(ADP-Ribose) Glycohydrolase