PARP3 Protein
Quick Overview for PARP3 Protein (ABIN7939433)
Target
See all PARP3 ProteinsProtein Type
Origin
Source
Application
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Purpose
- Recombinant PARP-3 protein
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Poly (ADP-Ribose) Polymerase Family, Member 3 (PARP3) (AA 1-533) protein (GST tag)
PARP3 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Poly (ADP-Ribose) Polymerase Family, Member 3 (PARP3) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)PARP3 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Recombinant PARP3 protein is supplied in 25 mM HEPES pH 7.5, 300 mM NaCl, 20 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.
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Handling Advice
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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Storage
- -80 °C
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Storage Comment
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- PARP3 (Poly (ADP-Ribose) Polymerase Family, Member 3 (PARP3))
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Alternative Name
- PARP-3
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Background
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Protein Background: PARP3 (Protein mono-ADP-ribosyltransferase PARP3), also known as ADPRT3, ADPRTL2, ADPRTL3, ARTD3, IRT1 and PADPRT-3. PARP3 is a Mono-ADP-ribosyltransferase that mediates mono-ADP ribosylation of target proteins and plays a key role in the response to DNA damage. Mediates mono-ADP-ribosylation of glutamate, aspartate or lysine residues on target proteins. Involved in DNA repair by mediating mono-ADP-ribosylation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism, such as histone H2B, XRCC5 and XRCC6. Involved in single-strand break repair by catalyzing mono-ADP-ribosylation of histone H2B on 'Glu-2' (H2BE2ADPr) of nucleosomes containing nicked DNA.
Short Description: Recombinant PARP3 protein was expressed in a baculovirus expression system as the full-length protein (accession number NP_005476.4) with an N-terminal His and FLAG tag. The molecular weight of the protein is 64.6 kDa.
Aliases: Protein mono ADP ribosyltransferase PARP3, ADPRT3, ARTD3, IRT1
Target
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