RANBP2 Protein (AA 2553-2838)

Catalog No. ABIN7939502

Recombinant RANBP2 protein expressed in Escherichia coli (E. coli).

Quick Overview for RANBP2 Protein (AA 2553-2838) (ABIN7939502)

Target: RANBP2 (RAN Binding Protein 2 (RANBP2))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Application: Activity Assay (AcA), Functional Studies (Func), Screening Assay (ScA)

Product Details

Protein Characteristics: AA 2553-2838

Purpose: Recombinant RANBP2 (2553-2838) protein

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Recombinant RANBP2 (2553-2838) protein is supplied in 25 mM Tris pH 8.0, 300 mM NaCl, 20 % glycerol, 0.5 mM TCEP.

Handling Advice: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Storage: -80 °C

Storage Comment: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Target Details

Target: RANBP2 (RAN Binding Protein 2 (RANBP2))

Alternative Name: RANBP2

Background:

Protein Background: RANBP2 (E3 SUMO-protein ligase RanBP2) is a E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Could also have isomerase or chaperone activity and may bind RNA or DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1.

Short Description: Recombinant RANBP2 (2553-2838) protein that includes amino acids 2553-2838 of human RANBP2 protein (accession number NP_006258.3) was expressed in E. coli and contains an N-terminal His tag with a molecular weight of 34.05 kDa. The purity of the protein is ≥ 90 % by SDS-PAGE.

Aliases: E3 SUMO-protein ligase, RanBP2, NUP358, ADANE, ANE1, P270, TRP1

Pathways: Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus