RHEB Protein

Catalog No. ABIN7939503

This Recombinant RHEB protein is expressed in Escherichia coli (E. coli).

Quick Overview for RHEB Protein (ABIN7939503)

Target: RHEB (Ras Homolog Enriched in Brain (RHEB))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Application: Activity Assay (AcA), Functional Studies (Func), Screening Assay (ScA)

Product Details

Purpose: Recombinant RHEB protein

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Recombinant RHEB protein is supplied in 25 mM Tris 8.0, 300 mM NaCl, 20 % glycerol, 0.5 mM TCEP.

Handling Advice: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Storage: -80 °C

Storage Comment: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Target Details

Target: RHEB (Ras Homolog Enriched in Brain (RHEB))

Alternative Name: RHEB

Background:

Protein Background: RHEB (GTP-binding protein Rheb) is a is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in the regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22.

Short Description: Recombinant RHEB protein that includes full length of the human RHEB protein (accession number NP_005605.1) was expressed in E.coli cells with an C-terminal His tag, The molecular weight of the protein is 21.56 kDa.

Aliases: GTP-binding protein Rheb, RHEB2, Ras Homolog Enriched In Brain 2

Pathways: RTK Signaling