RPS6KA1 Protein
Quick Overview for RPS6KA1 Protein (ABIN7939514)
Target
See all RPS6KA1 ProteinsProtein Type
Origin
Source
Application
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Purpose
- Recombinant RPS6KA1/RSK1 protein
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Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 (RPS6KA1) (AA 1-724) protein (His tag)
custom-made RPS6KA1 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 (RPS6KA1) (AA 1-735) protein (His tag)custom-made RPS6KA1 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 (RPS6KA1) (AA 1-735) protein (GST tag)RPS6KA1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 (RPS6KA1) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)RPS6KA1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Recombinant RPS6KA1 / RSK1 protein is supplied in 25 mM HEPES NaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.
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Handling Advice
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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Storage
- -80 °C
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Storage Comment
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- RPS6KA1 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 (RPS6KA1))
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Alternative Name
- RPS6KA1 & RSK1
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Background
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Protein Background: RPS6KA1 - (Ribosomal Protein S6 Kinase A1) is a serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77. This protein regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. Diseases associated with RPS6KA1 include Coffin-Lowry Syndrome and Tuberous Sclerosis.
Short Description: Recombinant RPS6KA1 / RSK1 protein was expressed in baculovirus expression system as the full length protein (accession number NP_002944.2) with a N-terminal FLAG tag. The molecular weight of the protein is 84 kDa.
Aliases: Ribosomal Protein S6 Kinase A1
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Pathways
- MAPK Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades
Target
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