UBE2A Protein
Quick Overview for UBE2A Protein (ABIN7939675)
Target
See all UBE2A (ube2a) ProteinsProtein Type
Origin
Source
Application
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Purpose
- Recombinant UBE2A protein
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Ubiquitin-Conjugating Enzyme E2A (ube2a) (AA 1-152) protein (His tag)
custom-made ube2a Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Ubiquitin-Conjugating Enzyme E2A (ube2a) (AA 1-152) protein (GST tag)ube2a Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Ubiquitin-Conjugating Enzyme E2A (ube2a) (AA 1-152) protein (His tag)ube2a Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % SDS
Ubiquitin-Conjugating Enzyme E2A (ube2a) (AA 1-152) protein (His-IF2DI Tag)ube2a Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Recombinant UBE2A protein is supplied in 25 mM Tris 8.0, 300 mM NaCl, 20 % glycerol, 0.5 mM TCEP.
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Handling Advice
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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Storage
- -80 °C
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Storage Comment
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- UBE2A (ube2a) (Ubiquitin-Conjugating Enzyme E2A (ube2a))
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Alternative Name
- UBE2A
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Background
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Protein Background: UBE2A (Ubiquitin-conjugating enzyme E2 A) also known as HHR6A,MRXS30, MRXSN, RAD6A, and UBC. UBE2A is a member of the E2 ubiquitin-conjugating enzyme family which is required for post-replicative DNA damage repair and plays an important role in various cellular processes. UBE2A can accept ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Required for post replication repair of UV-damaged DNA.
Short Description: Recombinant UBE2A protein that includes full length of human UBE2A protein (accession number NP_003327.2) was expressed in E. coli and contains an N-terminal His tag with a molecular weight of 19.48 kDa. The purity of the protein is ≥ 95 % by SDS-PAGE.
Aliases: Ubiquitin conjugating enzyme E2 A, HHR6A, MRXS30, MRXSN, RAD6A, UBC
Target
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