UBE2D2 Protein
Quick Overview for UBE2D2 Protein (ABIN7939683)
Target
See all UBE2D2 ProteinsProtein Type
Origin
Source
Application
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Purpose
- Recombinant UBE2D2 protein
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Ubiquitin-Conjugating Enzyme E2D 2 (UBE2D2) (AA 1-147) protein (His tag)
custom-made UBE2D2 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Ubiquitin-Conjugating Enzyme E2D 2 (UBE2D2) (AA 1-147) protein (GST tag)UBE2D2 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP
Ubiquitin-Conjugating Enzyme E2D 2 (UBE2D2) (AA 1-147) proteinUBE2D2 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % SDS
Ubiquitin-Conjugating Enzyme E2D 2 (UBE2D2) (AA 1-147) protein (His tag)UBE2D2 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. ELISA, WB
Ubiquitin-Conjugating Enzyme E2D 2 (UBE2D2) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)UBE2D2 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Ubiquitin-Conjugating Enzyme E2D 2 (UBE2D2) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)UBE2D2 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Recombinant UBE2D2 protein is supplied in 25 mM Tris 7.4, 300 mM NaCl, 20 % glycerol, 0.5 mM TCEP.
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Handling Advice
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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Storage
- -80 °C
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Storage Comment
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- UBE2D2 (Ubiquitin-Conjugating Enzyme E2D 2 (UBE2D2))
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Alternative Name
- UBE2D2
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Background
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Protein Background: UBE2D2 (Ubiquitin-conjugating enzyme E2 D2) also known as E2(17) KB2, PUBC1, UBC4, UBC4/5, UBCH4 and UBCH5B. UBE2D2 is a member of the E2 ubiquitin-conjugating enzyme family which is required for post replicative DNA damage repair and plays an important role in various cellular processes. UBE2D2 can accept ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6 AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2 mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by RIGI in response to viral infection.
Short Description: Recombinant UBE2D2 protein that includes full length of human UBE2D2 protein (accession number NP_003330.1) was expressed in E. coli and contains an N-terminal His tag with a molecular weight of 18.90 kDa. The purity of the protein is ≥ 70 % by SDS-PAGE.
Aliases: Ubiquitin conjugating enzyme E2 D2, E2(17)KB2, PUBC1, UBC4, UBC4/5, UBCH4, UBCH5B
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Pathways
- Activation of Innate immune Response, Toll-Like Receptors Cascades
Target
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