UBA1 Protein
Quick Overview for UBA1 Protein (ABIN7939723)
Target
See all UBA1 ProteinsProtein Type
Origin
Source
Application
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Purpose
- Recombinant UBA1 protein
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Ubiquitin-Like Modifier Activating Enzyme 1 (UBA1) (AA 1-1058) protein (GST tag)
UBA1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Ubiquitin-Like Modifier Activating Enzyme 1 (UBA1) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)UBA1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Recombinant UBA1 protein is supplied in 25 mM HEPES pH 7.5, 500 mM NaCl, 20 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.
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Handling Advice
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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Storage
- -80 °C
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Storage Comment
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- UBA1 (Ubiquitin-Like Modifier Activating Enzyme 1 (UBA1))
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Alternative Name
- UBA1
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Background
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Protein Background: UBA1 (Ubiquitin-like modifier-activating) also known as A1S9, A1S9T, A1ST, AMCX1, CFAP124, GXP1, POC20, SMAX2, UBA1A, UBE1, UBE1X and VEXAS. UBA1 catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites.
Short Description: Recombinant UBA1 protein that includes full length of human UBA1 protein (accession number NP_003325.2) was expressed in Sf9 cells and contains an N-terminal FLAG tag with a molecular weight of 119.12 kDa. The purity of the protein is ≥ 95 % by SDS-PAGE.
Aliases: Ubiquitin-like modifier-activating, A1S9, A1S9T, A1ST, GXP1, UBE1, A1S9T, AMCX1, POC20, SMAX2, UBA1A, UBE1X, CFAP124
Target
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