ERBB4 Protein (AA 682-993)

Catalog No. ABIN7939735

Recombinant ERBB4 protein expressed in Baculovirus infected Insect Cells.

Quick Overview for ERBB4 Protein (AA 682-993) (ABIN7939735)

Target: ERBB4 (V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4))

Protein Type: Recombinant

Origin: Human

Source: Baculovirus infected Insect Cells

Application: Activity Assay (AcA), Screening Assay (ScA), Functional Studies (Func)

Product Details

Protein Characteristics: AA 682-993

Purpose: Recombinant HER4 / ErbB4 (682-993) protein

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Recombinant HER4 / ErbB4 (682-993) protein is supplied in 25 mM HEPES-NaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100, and 0.5 mM TCEP.

Handling Advice: Avoid repeated freeze/thaw cycles,keep on ice when not in storage

Storage: -80 °C

Storage Comment: Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Target Details

Target: ERBB4 (V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4))

Alternative Name: HER4 & ErbB4

Background:

Protein Background: HER4, also known as ErbB4 (Erb-B2 Receptor Tyrosine Kinase 4) is a tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. It is required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation and is required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. It is also necessary for mammary gland differentiation, induction of milk proteins and lactation. HER4 acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF and mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Mutations in HER4 have been identified in various cancer types including melanoma, lung adenocarcinoma and medulloblastoma.

Short Description: Recombinant HER4 / ErbB4 (682-993) protein that includes amino acids 682-993 of human HER4 protein (accession number NP_005226.1) was expressed in a baculovirus expression system, and contains an N-terminal FLAG tag. The molecular weight of the protein is 36.6 kDa.

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway