XRCC1 Protein
Quick Overview for XRCC1 Protein (ABIN7939755)
Target
See all XRCC1 ProteinsProtein Type
Origin
Source
Application
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Purpose
- Recombinant XRCC1 protein
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X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 1 (XRCC1) (AA 534-633) protein (GST tag)
XRCC1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 1 (XRCC1) (AA 1-633) protein (GST tag)XRCC1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 1 (XRCC1) protein (Myc-DYKDDDDK Tag)XRCC1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Buffer
- Recombinant XRCC1 protein is supplied at in 25 mM HEPES pH 7.5, 300 mM NaCl, 20 % glycerol, 0.04 % Triton X-100, 0.5 mM TCEP.
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Handling Advice
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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Storage
- -80 °C
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Storage Comment
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- XRCC1 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 1 (XRCC1))
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Alternative Name
- XRCC1
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Background
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Protein Background: XRCC1 (DNA repair protein XRCC1) also known as RCC and SCAR26. XRCC1 is a scaffold protein that is recruited to SSBs by PARP1 and/or PARP2 activity through direct interaction betweenpoly (ADP-ribose) and the central BRCT domain in XRCC1. XRCC1 in turn interacts with and recruits the enzymes required for SSB repair, including DNA polymerase b, DNA ligase III, polynucleotide kinase/phosphatase and aprataxin. Hereditarymutations in XRCC1 and some of these protein partners result inneurodevelopmental disorders and/or progressive neurodegeneration.
Short Description: Recombinant XRCC1 protein that includes full length of human XRCC1 protein (accession number NP_006288.2) was expressed in Sf9 cells and contains an C-terminal His-FLAG tag with a molecular weight of 72.01 kDa. The purity of the protein is ≥ 80 % by SDS-PAGE.
Aliases: RCC, SCAR26
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Pathways
- DNA Damage Repair
Target
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