ApoE3 Protein

Catalog No. ABIN935201

Product Details

Target: ApoE3 (Apolipoprotein E3 (ApoE3))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Sequence: MKVEQAVETE PEPELRQQTE WQSGQRWELA LGRFWDYLRW VQTLSEQVQE ELLSSQVTQE LRALMDETMK ELKAYKSELE EQLTPVAEET RARLSKELQA AQARLGADME DVCGRLVQYR GEVQAMLGQS TEELRVRLAS HLRKLRKRLL RDADDLQKRL AVYQAGAREG AERGLSAIRE RLGPLVEQGR VRAATVGSLA GQPLQERAQA WGERLRARME EMGSRTRDRL DEVKEQVAEV RAKLEEQAQQ IRLQAEAFQA RLKSWFEPLV EDMQRQWAGL VEKVQAAVGT SAAPVPSDNH

Characteristics: Purified recombinant Human ApoE3 protein
Expression System: E.coli

Purity: > 90 % pure

Endotoxin Level: < 0.1 ng per µg (1 EU/µg).

Application Details

Application Notes: Each Investigator should determine their own optimal working dilution for specific applications.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute in 20 mM Sodium Phosphate, pH 7.8, and 0.5 mM DTT to a concentration of 1.0 mg/mL. Do not vortex. This solution can be stored at 4 °C for one week.

Buffer: Lyophilized from 20 mM Na3PO4, pH 7.8, with 0.5 mM DTT.

Preservative: Dithiothreitol (DTT)

Precaution of Use: This product contains Dithiothreitol: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.

Target Details

Target: ApoE3 (Apolipoprotein E3 (ApoE3))

Alternative Name: ApoE3 (ApoE3 Products)

Background: ApoE3 belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solublization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE exists in three major isoforms, E2, E3, and E4, which differ from one another by a single amino-acid substitution. E3 is the most common isoform and is present in 40-90 % of the population.
Alternative Names: Apoprotein E3 protein, Apo-E3 protein, Apo E3 protein, ApoE3, ApoE 3, ApoE-3 protein, ApoE-3, ApoE 3 protein

Molecular Weight: 34.0 kDa

Pathways: Regulation of Cell Size, Lipid Metabolism