TNFSF9 Protein
Quick Overview for TNFSF9 Protein (ABIN935240)
Target
See all TNFSF9 ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Sequence
- MREGPELSPD DPAGLLDLRQ GMFAQLVAQN VLLIDGPLSW YSDPGLAGVS LTGGLSYKED TKELVVAKAG VYYVFFQLEL RRVVAGEGSG SVSLALHLQP LRSAAGAAAL ALTVDLPPAS SEARNSAFGF QGRLLHLSAG QRLGVHLHTE ARARHAWQLT QGATVLGLFR VTPEIPAGLP SPRSE
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Characteristics
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Purified recombinant Human CD137 L protein
Expression System: E.coli
Bioactivity: Determined by the dose-dependent stimulation of IL-8 production by human PBMC. The ED50 for this effect is 5-10 ng/mL. Please Note: Results may vary with PBMC donors. -
Endotoxin Level
- < 0.1 ng per µg (1 EU/µg).
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Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9) (AA 71-254), (Trimer) (Active) protein (Fc Tag,DYKDDDDK Tag)
TNFSF9 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9) (AA 71-254), (Trimer) (Active) protein (His-DYKDDDDK Tag)TNFSF9 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9) (AA 68-251) (Active) protein (hFc Tag)TNFSF9 Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9) (AA 71-254), (Trimer) (Active) protein (Fc Tag,Biotin,DYKDDDDK Tag)TNFSF9 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 90 % as determined by HPLC Active
Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9) (AA 1-254) protein (His tag)custom-made TNFSF9 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9) (AA 1-309) protein (His tag)custom-made TNFSF9 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9) protein (mFc-His Tag)TNFSF9 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9) (AA 50-254) protein (His-DYKDDDDK-Strep II Tag)TNFSF9 Origin: Human Host: HEK-293T Cells Recombinant SDS, WB, ELISA, PI
Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9) (Active) protein (His tag)TNFSF9 Origin: Mouse Host: Human Cells Recombinant > 95 % as determined by SDS-PAGE Active
Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9) (AA 71-254) protein (His-IF2DI Tag)TNFSF9 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- Supplied as a lyophilized powder.
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- 4 °C/-20 °C
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Storage Comment
- Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.
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- TNFSF9 (Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9))
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Alternative Name
- CD137L
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Background
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CD137L or 4-1BBL, a member of the TNF superfamily, is expressed in B cells, dendritic cells, activated T cells and macrophages. 4-1BBL binds to its receptor 4-1BB, and provides a co-stimulatory signal for T cell activation and expansion. The human 4-1BBL gene codes for a 254 amino acid type II transmembrane containing a 28 amino acid cytoplasmic domain, a 21 amino acid transmembrane domain, and a 205 amino acid extracellular domain. The soluble form of 4-1BBL contains the TNF-like portion of the extracellular domain of 4-1BBL.
Alternative Names: TNFSF9 protein, CDL-137 protein, CDL 137 protein, 4-1BB protein, CDL-137, CD137L, CDL 137 -
Molecular Weight
- 19.5 kDa
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Pathways
- Activated T Cell Proliferation, Cancer Immune Checkpoints
Target
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