Betacellulin Protein (BTC)
Quick Overview for Betacellulin Protein (BTC) (ABIN935244)
Target
See all Betacellulin (BTC) ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Sequence
- DGNSTRSPET NGLLCGDPEE NCAATTTQSK RKGHFSRCPK QYKHYCIKGR CRFVVAEQTP SCVCDEGYIG ARCERVDLFY
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Characteristics
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Purified recombinant Human Betacellulin protein
Expression System: E.coli
Bioactivity: The ED50 was determined by the dose-dependent stimulation of the proliferation of Mouse Balb/3T3 cells is ? 0.05 ng/mL, corresponding to a specific activity of ? 2 x 10^7units/mg. -
Endotoxin Level
- < 0.1 ng per µg (1 EU/µg).
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Betacellulin (BTC) (AA 1-178) protein (GST tag)
BTC Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Betacellulin (BTC) (AA 32-111) protein (His-IF2DI Tag)BTC Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Betacellulin (BTC) (AA 32-111) protein (His-IF2DI Tag)BTC Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Betacellulin (BTC) (AA 32-111) protein (Fc Tag)BTC Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- Supplied as a lyophilized powder.
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- 4 °C/-20 °C
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Storage Comment
- Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.
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- Betacellulin (BTC)
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Alternative Name
- Betacellulin
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Background
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Betacellulin is an EGF-related polypeptide growth factor that signals through the EGF receptor. It is produced in several tissues, including the pancreas, small intestine, and in certain tumor cells. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Human Betacellulin is initially synthesized as a glycosylated 32.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce the mature sequence. Recombinant human Betacellulin is a 9.0 kDa monomeric protein, containing 80 amino residues, which comprises the mature EGF homologous portion of the Betacellulin protein.
Alternative Names: BTC protein, beta Cellulin protein -
Molecular Weight
- 9 kDa
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Pathways
- RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Target
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