Epigen Protein
Quick Overview for Epigen Protein (ABIN935330)
Target
See all Epigen (EPGN) ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Sequence
- AVTVTPPITA QQADNIEGPI ALKFSHLCLE DHNSYCINGA CAFHHELEKA ICRCFTGYTG ERCEHLTLTS YA
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Characteristics
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Purified recombinant Human Epigen protein
Expression System: E.coli
Bioactivity: Determined by the dose-dependent stimulation of the proliferation of Mouse Balb/3T3 cells. The expected ED50 for this effect is 150-300 ng/mL. -
Endotoxin Level
- < 0.1 ng per µg (1 EU/µg).
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Epithelial Mitogen (EPGN) (AA 24-95) protein (His tag)
EPGN Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Epithelial Mitogen (EPGN) (AA 1-133) protein (GST tag)EPGN Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Epithelial Mitogen (EPGN) (AA 23-110) protein (His tag)EPGN Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 90% by SDS-PAGE SDS
Epithelial Mitogen (EPGN) (AA 23-110) protein (His tag)EPGN Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % by SDS - PAGE SDS
Epithelial Mitogen (EPGN) protein (Myc-DYKDDDDK Tag)EPGN Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- Supplied as a lyophilized powder.
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- RT/-20 °C
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- Epigen (EPGN) (Epithelial Mitogen (EPGN))
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Alternative Name
- Epigen
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Background
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Epigen is an EGF-related polypeptide growth factor that signals through the ErbB receptor-1. It is produced in several tissues, including the testis, liver, heart and in certain tumor cells. Epigen is mitogenic for fibroblasts and epithelial cells. Human Epigen is initially synthesized as a glycosylated 14.7 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a mature soluble sequence. Recombinant human Epigen is a 7.9 kDa monomeric protein, containing 72 amino acid residues, which comprises the EGF homologous portion of the Epigen precursor.
Alternative Names: EPG protein, Epithelial mitogen protein -
Molecular Weight
- 7.9 kDa
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Pathways
- RTK Signaling, EGFR Signaling Pathway
Target
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