Midkine Protein
Quick Overview for Midkine Protein (ABIN935627)
Target
See all Midkine (MDK) ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Sequence
- VAKKKDKVKK GGPGSECAEW AWGPCTPSSK DCGVGFREGT CGAQTQRIRC RVPCNWKKEF GADCKYKFEN WGACDGGTGT KVRQGTLKKA RYNAQCQETI RVTKPCTPKT KAKAKAKKGK GKD
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Characteristics
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Purified recombinant Human Midkine protein
Expression System: E.coli
Bioactivity: Determined by its ability to chemoattract human neutrophils using a concentration range of 0.1-10.0 ng/mL. -
Endotoxin Level
- < 0.1 ng per µg (1 EU/µg).
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Midkine (Neurite Growth-Promoting Factor 2) (MDK) (Active) protein
MDK Origin: Human Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS-PAGE Func Active
Midkine (Neurite Growth-Promoting Factor 2) (MDK) (AA 23-140) protein (His tag)MDK Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by Tris-Bis PAGE
Midkine (Neurite Growth-Promoting Factor 2) (MDK) (AA 21-143) protein (His-Avi Tag)MDK Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by Tris-Bis PAGE
Midkine (Neurite Growth-Promoting Factor 2) (MDK) (AA 21-140) protein (His tag)MDK Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Midkine (Neurite Growth-Promoting Factor 2) (MDK) (AA 21-143) protein (Fc Tag)MDK Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Midkine (Neurite Growth-Promoting Factor 2) (MDK) (AA 23-143) protein (Fc Tag)MDK Origin: Cynomolgus Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Midkine (Neurite Growth-Promoting Factor 2) (MDK) (AA 21-143) protein (His tag)MDK Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % by SDS - PAGE SDS
Midkine (Neurite Growth-Promoting Factor 2) (MDK) (AA 1-143) protein (GST tag)MDK Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Reconstitute in water to a concentration of 0.1-1.0 mg/mL.
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Buffer
- Lyophilized from PBS, pH 7.4.
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- RT/-20 °C
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- Midkine (MDK) (Midkine (Neurite Growth-Promoting Factor 2) (MDK))
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Alternative Name
- Midkine
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Background
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Midkine (MK) and its functionally-related protein Pleiotrophin are heparin-binding neurotrophic factors that signal through the same receptor, known as anaplastic lymphoma kinase (ALK). MK plays an important regulatory role in epithelial-mesenchymal interactions during fetal development and in postnatal lung development. MK chemoattracts embryonic neurons, neutrophils and macrophages, and by signaling through the ALK receptor it exerts angiogenic, growth and survival activities during tumorgenesis.
Alternative Names: MK protein, NEGF-2 protein -
Molecular Weight
- 13.4 kDa
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Pathways
- RTK Signaling, M Phase, Skeletal Muscle Fiber Development
Target
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