NGFB Protein

Catalog No. ABIN935676

This Recombinant NGFB protein is expressed in Escherichia coli (E. coli).

Quick Overview for NGFB Protein (ABIN935676)

Target: NGFB (Nerve Growth Factor beta (NGFB))

Protein Type: Recombinant

Biological Activity: Active

Origin: Human

Source: Escherichia coli (E. coli)

Purity: > 98 % pure

Product Details

Sequence: SSSHPIFHRG EFSVCDSVSV WVGDKTTATD IKGKEVMVLG EVNINNSVFK QYFFETKCRD PNPVDSGCRG IDSKHWNSYC TTTHTFVKAL TMDGKQAAWR FIRIDTACVC VLSRKAVR

Characteristics: Purified recombinant Human beta NGF protein
Expression System: E.coli
Bioactivity: Determined by its ability to stimulate chick E9 DRG neurite outgrowth. The ED50 is 1 x 10^6 units/mg.

Endotoxin Level: < 0.1 ng per µg (1 EU/µg).

Application Details

Application Notes: Each Investigator should determine their own optimal working dilution for specific applications.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute in water to a concentration of 0.1 - 1.0 mg/mL.

Buffer: Supplied lyophilized with no additives.

Preservative: Without preservative

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.

Target Details

Target: NGFB (Nerve Growth Factor beta (NGFB))

Alternative Name: beta NGF

Background: Beta-NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Beta-NGF is a potent neurotrophic factor that signals through its receptor beta-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. Beta-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival.
Alternative Names: beta-NGF protein, Nerve Growth factor protein, NGF-beta protein

Molecular Weight: 13.5 kDa

Pathways: NF-kappaB Signaling, RTK Signaling, Regulation of Cell Size