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NOG Protein

NOG Origin: Human Host: HEK-293T Cells Recombinant > 98 % pure Active
Catalog No. ABIN935687
  • Target See all NOG Proteins
    NOG (Noggin (NOG))
    Protein Type
    Recombinant
    Biological Activity
    Active
    Origin
    • 15
    • 12
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    Human
    Source
    • 18
    • 9
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    HEK-293T Cells
    Sequence
    QHYLHIRPAP SDNLPLVDLI EHPDPIFDPK EKDLNETLLR SLLGGHYDPG FMATSPPEDR PGGGGGAAGG AEDLAELDQL LRQRPSGAMP SEIKGLEFSE GLAQGKKQRL SKKLRRKLQM WLWSQTFCPV LYAWNDLGSR FWPRYVKVGS CFSKRSCSVP EGMVCKPSKS VHLTVLRWRC QRRGGQRCGW IPIQYPIISE CKCSC
    Characteristics
    Purified recombinant Human Noggin protein
    Expression System: 293 cells
    Bioactivity: Determined by its ability to inhibit 5.0 ng/mL of BMP-4 induced alkaline phosphatase production by ATDC chondrogenic cells. The expected ED50 for this effect is 2.0-3.0 ng/mL of Noggin.
    Purity
    > 98 % pure
    Endotoxin Level
    < 0.1 ng per µg (1 EU/µg).
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  • Application Notes
    Each Investigator should determine their own optimal working dilution for specific applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Reconstitute in water to a concentration of 0.1 - 1.0 mg/mL.
    Buffer
    Supplied lyophilized with no additives.
    Preservative
    Without preservative
    Handling Advice
    Avoid repeated freeze/thaw cycles.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.
  • Target
    NOG (Noggin (NOG))
    Alternative Name
    Noggin (NOG Products)
    Synonyms
    SYM1 Protein, SYNS1 Protein, nog-A Protein, nog1 Protein, noggin-1 Protein, noggin Protein, noggin Protein, noggin L homeolog Protein, noggin protein Protein, NOG Protein, Nog Protein, nog.L Protein, noggin Protein
    Background
    Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF beta family and regulate their activity by inhibiting their access to signaling receptors. The interplay between TGF beta ligands and their natural antagonists has major biological significance during development processes, in which cellular response can vary considerably depending upon the local concentration of the signaling molecule. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently, Noggin has been shown to modulate the activities of other BMPs including BMP-2, -7, -13, and -14. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system.
    Alternative Names: SYM1 protein, NOG protein, SYM 1 protein, SYNS 1 protein, Symphalangism 1 (proximal) protein, Synostoses (multiple) syndrome 1 protein, SYNS1 protein
    Molecular Weight
    46 kDa
    Pathways
    Stem Cell Maintenance, Tube Formation
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