Thrombopoietin Protein (THPO)
Quick Overview for Thrombopoietin Protein (THPO) (ABIN935820)
Target
See all Thrombopoietin (THPO) ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Sequence
- SPAPPACDLR VLSKLLRDSH VLHSRLSQCP EVHPLPTPVL LPAVDFSLGE WKTQMEETKA QDILGAVTLL LEGVMAARGQ LGPTCLSSLL GQLSGQVRLL LGALQSLLGT QLPPQGRTTA HKDPNAIFLS FQHLLRGKVR FLMLVGGSTL CVRRAPPTTA VPSRTSLVLT LNEL
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Characteristics
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Purified recombinant Human Thrombopoietin protein
Expression System: E.coli
Bioactivity: The ED50 as determined by the dose-dependent stimulation of the proliferation of human MO7e cells was found to be ? 1.0 ng/mL, corresponding to a specific activity of ? 1 x 10^6 units/mg. -
Endotoxin Level
- < 0.1 ng per µg (1 EU/µg).
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Thrombopoietin (THPO) (AA 22-356) (Active) protein
THPO Origin: Mouse Host: CHO Cells Recombinant > 95 % as analyzed by SDS-PAGE. Active
Thrombopoietin (THPO) protein (His tag)THPO Origin: Mouse Host: Human Cells Recombinant > 95 % as determined by SDS-PAGE
Thrombopoietin (THPO) (AA 23-195) protein (His tag)THPO Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Thrombopoietin (THPO) (AA 22-195) protein (His-IF2DI Tag)THPO Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Thrombopoietin (THPO) (AA 1-349) protein (GST tag)THPO Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Thrombopoietin (THPO) proteinTHPO Origin: Mouse Host: Escherichia coli (E. coli) Recombinant 97,00% SDS
Thrombopoietin (THPO) proteinTHPO Origin: Mouse Host: Escherichia coli (E. coli) Recombinant 97,00% SDS
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Reconstitute in water to a concentration of 0.1 - 1.0 mg/mL.
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Buffer
- Lyophilized from 10 mM sodium citrate, pH 3.0.
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- 4 °C/-20 °C
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Storage Comment
- Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.
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- Thrombopoietin (THPO)
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Alternative Name
- Thrombopoietin
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Background
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TPO is a lineage specific growth factor, produced in the liver, kidney and skeletal muscle. It stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets. Human and Mouse TPO exhibits cross-species reactivity.
Alternative Names: TPO protein, THPO protein, MGDF protein, c-MPL Ligand protein, Megakaryocyte colony-stimulating factor protein -
Molecular Weight
- 18.6 kDa
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Pathways
- JAK-STAT Signaling, Hormone Activity
Target
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