Thrombopoietin Protein (THPO)
Quick Overview for Thrombopoietin Protein (THPO) (ABIN935857)
Target
See all Thrombopoietin (THPO) ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Sequence
- SPVAPACDPR LLNKLLRDSH LLHSRLSQCP DVDPLSIPVL LPAVDFSLGE WKTQTEQSKA QDILGAVSLL LEGVMAARGQ LEPSCLSSLL GQLSGQVRLL LGALQGLLGT QLPLQGRTTA HKDPNALFLS LQQLLRGKVR FLLLVEGPTL CVRRTLPTTA VPSSTSQLLT LNKF
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Characteristics
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Purified recombinant Human Thrombopoietin protein
Expression System: E.coli
Bioactivity: The ED50 as determined by the dose-dependent stimulation of the proliferation of human MO7e cells was found to be 1 x 10^6 units/mg. -
Endotoxin Level
- < 0.1 ng per µg (1 EU/µg).
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Thrombopoietin (THPO) (AA 22-356) (Active) protein
THPO Origin: Mouse Host: CHO Cells Recombinant > 95 % as analyzed by SDS-PAGE. Active
Thrombopoietin (THPO) protein (His tag)THPO Origin: Mouse Host: Human Cells Recombinant > 95 % as determined by SDS-PAGE
Thrombopoietin (THPO) (AA 23-195) protein (His tag)THPO Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Thrombopoietin (THPO) (AA 22-195) protein (His-IF2DI Tag)THPO Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Thrombopoietin (THPO) (AA 1-349) protein (GST tag)THPO Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Thrombopoietin (THPO) proteinTHPO Origin: Mouse Host: Escherichia coli (E. coli) Recombinant 97,00% SDS
Thrombopoietin (THPO) proteinTHPO Origin: Mouse Host: Escherichia coli (E. coli) Recombinant 97,00% SDS
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Restore in water to a concentration of 0.5 - 1.0 mg/mL.
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Buffer
- Lyophilized from 10 mM Tris, pH 8.0.
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- 4 °C/-20 °C
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Storage Comment
- Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.
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- Thrombopoietin (THPO)
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Alternative Name
- Thrombopoietin
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Background
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TPO is a lineage specific growth factor, produced in the liver, kidney and skeletal muscle. It stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets. Human and Mouse TPO exhibits cross-species reactivity.
Alternative Names: c-MPL Ligand protein, TPO protein, THPO protein, Megakaryocyte colony-stimulating factor protein, MGDF protein -
Molecular Weight
- 18.7 kDa
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Pathways
- JAK-STAT Signaling, Hormone Activity
Target
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