VEGFB Protein
Quick Overview for VEGFB Protein (ABIN935902)
Target
See all VEGFB ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Sequence
- PVSQPDAPGH QRKVVSWIDV YTRATCQPRE VVVPLTVELM GTVAKQLVPS CVTVQRCGGC CPDDGLECVP TGQHQVRMQI LMIRYPSSQL GEMSLEEHSQ CECRPKKKDS AVKPDSPRPL CPRCTQHHQR PDPRTCRCRC RRRSFLRCQG RGLELNPDTC RCRKLRR
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Characteristics
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Purified recombinant Human VEGF B protein
Expression System: E.coli
Bioactivity: Determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC) in the presence of human VEGF165. The expected ED50 for this effect is 1.0-2.0 µg/mL. -
Endotoxin Level
- < 0.1 ng per µg (1 EU/µg).
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Vascular Endothelial Growth Factor B (VEGFB) (AA 1-207) protein (GST tag)
VEGFB Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Vascular Endothelial Growth Factor B (VEGFB) (Active) proteinVEGFB Origin: Human Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS-PAGE Func Active
Vascular Endothelial Growth Factor B (VEGFB) (AA 22-207) (Active) protein (His tag)VEGFB Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- Supplied as a lyophilized powder.
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- 4 °C/-20 °C
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Storage Comment
- Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.
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- VEGFB (Vascular Endothelial Growth Factor B (VEGFB))
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Alternative Name
- VEGF B
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Background
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VEGF-B, a member of the VEGF family, is a potent growth and angiogenic cytokine. It promotes DNA synthesis in endothelial cells, helps regulate angiogenesis and vascular permeability, and inhibits apoptosis in certain smooth muscle cells and neurons. VEGF-B is expressed in all tissues except the liver. It forms cell surfaced-associated disulfide linked homodimers and can form heterodimers with VEGF-A. There are two known isoforms, formed by alternative splicing, which have been designated VEGF-B167 and VEGF-B186. Both forms have identical amino-terminal sequences encoding a "cysteine knot" like structural motif, but differ in their carboxyl-terminal domains.
Alternative Names: VEGF-related factor protein, VRF protein, Vascular Endothelial Growth Factor-B protein -
Pathways
- RTK Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals
Target
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