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VEGFB Protein

VEGFB Origin: Human Host: Escherichia coli (E. coli) Recombinant > 98 % pure Active
Catalog No. ABIN935902
  • Target See all VEGFB Proteins
    VEGFB (Vascular Endothelial Growth Factor B (VEGFB))
    Protein Type
    Recombinant
    Biological Activity
    Active
    Origin
    • 10
    • 3
    • 3
    • 1
    • 1
    Human
    Source
    • 9
    • 3
    • 2
    • 2
    • 1
    Escherichia coli (E. coli)
    Sequence
    PVSQPDAPGH QRKVVSWIDV YTRATCQPRE VVVPLTVELM GTVAKQLVPS CVTVQRCGGC CPDDGLECVP TGQHQVRMQI LMIRYPSSQL GEMSLEEHSQ CECRPKKKDS AVKPDSPRPL CPRCTQHHQR PDPRTCRCRC RRRSFLRCQG RGLELNPDTC RCRKLRR
    Characteristics
    Purified recombinant Human VEGF B protein
    Expression System: E.coli
    Bioactivity: Determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC) in the presence of human VEGF165. The expected ED50 for this effect is 1.0-2.0 µg/mL.
    Purity
    > 98 % pure
    Endotoxin Level
    < 0.1 ng per µg (1 EU/µg).
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    Discover our top product VEGFB Protein
  • Application Notes
    Each Investigator should determine their own optimal working dilution for specific applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    Supplied as a lyophilized powder.
    Handling Advice
    Avoid repeated freeze/thaw cycles.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.
  • Target
    VEGFB (Vascular Endothelial Growth Factor B (VEGFB))
    Alternative Name
    VEGF B (VEGFB Products)
    Synonyms
    VEGFL Protein, VRF Protein, VEGF-B Protein, Vrf Protein, vascular endothelial growth factor B Protein, VEGFB Protein, Vegfb Protein
    Background
    VEGF-B, a member of the VEGF family, is a potent growth and angiogenic cytokine. It promotes DNA synthesis in endothelial cells, helps regulate angiogenesis and vascular permeability, and inhibits apoptosis in certain smooth muscle cells and neurons. VEGF-B is expressed in all tissues except the liver. It forms cell surfaced-associated disulfide linked homodimers and can form heterodimers with VEGF-A. There are two known isoforms, formed by alternative splicing, which have been designated VEGF-B167 and VEGF-B186. Both forms have identical amino-terminal sequences encoding a "cysteine knot" like structural motif, but differ in their carboxyl-terminal domains.
    Alternative Names: VEGF-related factor protein, VRF protein, Vascular Endothelial Growth Factor-B protein
    Pathways
    RTK Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals
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