IL-13 Protein (AA 19-132)
Quick Overview for IL-13 Protein (AA 19-132) (ABIN988034)
Target
See all IL-13 (IL13) ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Protein Characteristics
- AA 19-132
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Characteristics
- ED50 < 15 ng/mL, measured in a cell proliferation assay using TF-1 cells, corresponding to a specific activity of > 6.7x10^5 units/mg.
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Endotoxin Level
- < 0.2 EU/μg, determined by LAL method.
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Interleukin 13 (IL13) (AA 21-132) protein (His-Avi Tag)
IL13 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Tris-Bis PAGE
Interleukin 13 (IL13) (AA 21-132) protein (Fc Tag)IL13 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 13 (IL13) (AA 19-132) protein (His tag)IL13 Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 13 (IL13) (AA 19-132) (Active) proteinIL13 Origin: Human Host: CHO Cells Recombinant > 95 % as analyzed by SDS-PAGE. Active
Interleukin 13 (IL13) (AA 26-131) (Active) protein (His tag)IL13 Origin: Mouse Host: Human Cells Recombinant > 95 % as determined by SDS-PAGE Active
Interleukin 13 (IL13) (AA 21-132) protein (His-Avi Tag,Biotin)IL13 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Tris-Bis PAGE
Interleukin 13 (IL13) (AA 21-132) (Active) protein (Fc Tag)IL13 Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Interleukin 13 (IL13) (AA 21-132) (Active) protein (His tag,AVI tag,Biotin)IL13 Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Interleukin 13 (IL13) protein (mFc Tag)IL13 Origin: Human Host: Human Cells Recombinant >95 % as determined by reducing SDS-PAGE.
Interleukin 13 (IL13) (AA 22-131) protein (His tag)IL13 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Reconstituted in ddH2O or PBS at 100 μg/mL.
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Buffer
- Lyophilized after extensive dialysis against PBS.
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Storage
- -80 °C
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Storage Comment
- Lyophilized recombinant human Interleukin 13 (IL-13) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rhIL-13 should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.
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Expiry Date
- 6 months
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- IL-13 (IL13) (Interleukin 13 (IL13))
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Alternative Name
- Interleukin 13 (IL-13)
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Background
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Interleukin 13 (IL-13) is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1beta, TNF-alpha, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and mouse IL-13 is cross-species reactive.Recombinant human interleukin 13 expressed in CHO cells is glycosylated protein with molecular weight range from 25 to 45 kDa shown in non-reducing SDS-PAGE.
Synonyms: NC30 (Human), P600 (Murine),IL-13 (human) -
Molecular Weight
- 25-45 kDa, observed by non-reducing SDS-PAGE.
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UniProt
- P35225
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Pathways
- JAK-STAT Signaling, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Proton Transport
Target
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