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Human ADCC-Mediating Monoclonal Antibodies for Treatment and Prevention of HSV

NIH View original grant

New approaches such as monoclonal antibodies (mAbs) are needed to treat genital and neonatal herpes simplex virus (HSV) infections and reduce the frequency and magnitude of viral reactivation. Technological advances that reduce manufacturing costs, extend monoclonal antibody half-life and augment cytolytic activity highlight the potential for mAbs to alter the natural history of lifelong infections such as HSV. The few mAbs in preclinical or clinical development were designed to provide neutrali

Matching Reagent Categories (9)

Anti-HSV Glycoprotein B Monoclonal Antibodies

Human or mouse monoclonal antibodies targeting HSV glycoprotein B, especially domain IV epitopes, for antiviral testing, ADCC studies, epitope mapping, and in vivo protection experiments against HSV-1 and HSV-2.

1 products found

anti-Glycoprotein B antibody (ABIN640662)

ADCC Bioassay Reagents for Human Fc Gamma Receptor Studies

Reagents to evaluate antibody-dependent cellular cytotoxicity, including Fcγ receptor-binding assay components, reporter bioassays, and tools compatible with human IgG1 and mouse IgG2c antibody formats.

20+ products found

Fc Fragment of IgG, High Affinity Ia, Receptor (CD64) (FCGR1A) ELISA Kit (ABIN6974132)

Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A) ELISA Kit (ABIN6955740)

Fc Fragment of IgG, Low Affinity IIIb, Receptor (CD16b) (FCGR3B) ELISA Kit (ABIN6955741)

Fc Fragment of IgG, Low Affinity IIb, Receptor (CD32) (FCGR2B) ELISA Kit (ABIN1889450)

Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A) ELISA Kit (ABIN838838)

Antibody-Dependent Cellular Phagocytosis Assay Reagents

Products for measuring antibody-dependent cellular phagocytosis of HSV antigen-coated targets, including labeled target particles, detection reagents, and assay kits for in vitro functional screening of monoclonal antibodies.

1 products found

Herpes Simplex Virus (HSV) protein (ABIN1684548)

Human PBMC and B-Cell Isolation Reagents

Cell isolation and sorting reagents for recovering peripheral blood mononuclear cells and B-cell populations from donors with chronic HSV infection for monoclonal antibody discovery and characterization.

280+ products found

anti-CD19 Molecule (CD19) (AA 20-291) antibody (ABIN7147133)

anti-CD19 Molecule (CD19) (AA 151-250) antibody (ABIN1387313)

anti-CD19 Molecule (CD19) (AA 96-281) antibody (ABIN6941101)

anti-CD19 Molecule (CD19) antibody (ABIN2855077)

anti-CD19 Molecule (CD19) (pTyr531) antibody (ABIN683623)

Anti-HSV Glycoprotein B Monoclonal Antibodies

Human or mouse monoclonal antibodies targeting HSV glycoprotein B, especially domain IV epitopes, for ADCC-focused antiviral studies, epitope mapping, and therapeutic testing against HSV-1 and HSV-2.

1 products found

anti-Glycoprotein B antibody (ABIN640662)

Antibody-Dependent Cellular Phagocytosis Assay Reagents for HSV

Assay reagents for evaluating antibody-dependent cellular phagocytosis mediated by HSV-specific monoclonal antibodies in vitro.

27+ products found

anti-Herpes Simplex Virus (HSV) antibody (ABIN344276)

anti-Herpes Simplex Virus (HSV) antibody (Biotin) (ABIN464638)

anti-Herpes Simplex Virus (HSV) antibody (FITC) (ABIN464698)

anti-Herpes Simplex Virus (HSV) antibody (HRP) (ABIN464757)

anti-Herpes Simplex Virus (HSV) antibody (ABIN576750)

ADCC Bioassay Reagents for HSV Antibody Studies

Reagents to measure antibody-dependent cellular cytotoxicity of anti-HSV antibodies, including Fc receptor-based assay tools and target antigens suitable for in vitro functional screening.

51+ products found

Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A) (AA 17-208) protein (His-Avi Tag,Biotin) (ABIN7536872)

Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A) (AA 17-208) protein (His-Avi Tag) (ABIN7536871)

Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A) (AA 17-254) protein (GST tag) (ABIN1353901)

Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A) (AA 17-208), (F176V) (Active) protein (His tag) (ABIN7678350)

Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A) (AA 17-206) protein (His tag) (ABIN6961127)

Human Fc Gamma Receptor Reagents

Human Fcγ receptor proteins, antibodies, or assay reagents for studying Fc-mediated activity of human IgG1 anti-HSV monoclonal antibodies and their ADCC function.

713+ products found

anti-Fc Fragment of IgG, High Affinity Ia, Receptor (CD64) (FCGR1A) (AA 200-292) antibody (ABIN3021695)

anti-Fc Fragment of IgG, Low Affinity IIa, Receptor (CD32) (FCGR2A) antibody (ABIN1497259)

anti-Fc Fragment of IgG, Low Affinity IIa, Receptor (CD32) (FCGR2A) antibody (ABIN1497264)

anti-Fc Fragment of IgG, Low Affinity IIb, Receptor (CD32) (FCGR2B) (pTyr292) antibody (ABIN761411)

anti-Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a) (FCGR3A) (AA 204-254) antibody (ABIN7449424)

Anti-HSV Glycoprotein Monoclonal Antibody Panels

Panels of monoclonal antibodies against multiple HSV surface glycoproteins for combination studies, breadth testing across clinical isolates, and evaluation of distinct antiviral mechanisms.

2 products found

anti-Herpes Simplex Virus Type 2, Glycoprotein D (HSV2 gD) antibody (ABIN7385593)

anti-Herpes Simplex Virus Type 2, Glycoprotein B (HSV2 gB) antibody (ABIN1825330)

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