Abstract The core in charge of antibody engineering and production will serve projects #4, as well as Cores #1 and #3. Polyclonal as well as monoclonal antibodies will be produced and distributed. The flow of work will be organized along the lines of 4 specific tasks. Task 1: Produce and characterize anti-glycan polyclonal and monoclonal antibodies. Following immunization, we will use two main approaches to produce antibodies: standard fusion to an immortal partner to produce monoclonal antibodi
Matching Reagent Categories (11)
Anti-Glycan Polyclonal Antibodies
Polyclonal antibodies raised against glycan antigens for large-scale detection, binding assays, and antibacterial immunology studies in animal-derived samples.
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Papain and Antibody Fragmentation Reagents
Papain and related proteolytic reagents for cleavage of full-length immunoglobulins to generate Fab fragments for downstream structural studies.
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Fab Antibody Fragments
Fab fragments derived from full-length antibodies or recombinant expression for crystallization, structural biology, and antigen-binding analysis.
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Recombinant IgA and IgM Antibodies
Recombinant IgA and IgM isotypes for studying glycan recognition, antibacterial activity, and isotype-specific effector functions.
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Reagents suitable for Biacore T200-based characterization of antibody-glycan interactions, including affinity and binding constant measurements.
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Recombinant Antibodies Expressed in CHO Cells
Recombinant paired heavy- and light-chain antibodies produced in CHO cells following single B-cell sequencing for re-expression and functional characterization.
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Anti-Glycan Monoclonal Antibodies
Monoclonal antibodies targeting glycans or polysaccharide antigens for antigen-binding studies, ELISA, and characterization of antibacterial antibody responses.
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Fc-Engineered Antibodies
Antibodies with grafted or mutated mouse or human Fc fragments to alter effector function, half-life, complement activation, and bacterial protein binding.
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Recombinant IgA and IgM Antibodies
Recombinant IgA and IgM antibodies for studying isotype-specific antibacterial functions, complement interactions, and glycan binding.
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Fab Fragment Antibodies
Fab fragments generated by papain cleavage or recombinant truncated heavy-chain expression for structural studies, crystallization, and antigen-binding analysis.
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Fc-Engineered Antibodies
Antibodies with modified, grafted, or mutated human or mouse Fc regions to alter complement activation, half-life, and bacterial protein binding properties.
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