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anti-Mouse (Murine) POLR2A Antibodies:
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Human Polyclonal POLR2A Primary Antibody for ICC, IF - ABIN4350645
Nordick, Hoffman, Betz, Jaehning: Direct interactions between the Paf1 complex and a cleavage and polyadenylation factor are revealed by dissociation of Paf1 from RNA polymerase II. in Eukaryotic cell 2008
Show all 11 Pubmed References
Human Monoclonal POLR2A Primary Antibody for ChIP, CyTOF - ABIN268311
Reid, Svejstrup: DNA damage-induced Def1-RNA polymerase II interaction and Def1 requirement for polymerase ubiquitylation in vitro. in The Journal of biological chemistry 2004
Show all 7 Pubmed References
Chicken Polyclonal POLR2A Primary Antibody for DB, WB - ABIN4350647
Hsin, Sheth, Manley: RNAP II CTD phosphorylated on threonine-4 is required for histone mRNA 3' end processing. in Science (New York, N.Y.) 2011
Show all 3 Pubmed References
Skill learning modulates RNA Pol II (show POLR2F Antibodies) poising at immediate early (show JUN Antibodies) genes in the adult striatum. These experiments demonstrate a novel phenomenon of learning induced transcriptional modulation in adult brain.
An H3K9/S10 (show PSMD6 Antibodies) methyl-phospho switch modulates Polycomb (show CBX2 Antibodies) and Pol II (show Pol II Antibodies) binding at repressed genes during differentiation.
Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription
These data indicate that, through cooperation with PolII (show Pol II Antibodies) and KDM6A (show KDM6A Antibodies), Spt6 (show SUPT6H Antibodies) orchestrates removal of H3K27me3, thus controlling developmental gene expression and cell differentiation.
site-specific p65 (show NFkBP65 Antibodies) phosphorylation targets NF-kappaB (show NFKB1 Antibodies) activity to particular gene subsets on a global level by influencing p65 (show NFkBP65 Antibodies) and p-RNAP II (show Pol II Antibodies) promoter recruitment
Data show that that B2 RNA, when present with Pol II (show Pol II Antibodies) in promoter-bound complexes, specifically represses CTD phosphorylation by TFIIH (show GTF2H4 Antibodies).
investigation of contribution of largest subunit of phosphorylated RNAP II (show Pol II Antibodies) to onset of minor gene activation in zygote; nuclear localization of RNAP II (show Pol II Antibodies) in 1-cell zygote; regulation of RNAP II (show Pol II Antibodies) expression by deposition of acetylated histone on promoter
involvement of RPB1, the largest subunit of RNA polymerase II (RNAP II (show Pol II Antibodies)), in the regulation of transcriptional silencing mechanism
Reduction in RNA Pol II (show POLR2F Antibodies) association is indicative of interruption in direct interactions of RNA Pol II (show POLR2F Antibodies) with PEPCK (show PEPCK Antibodies) promoter, with general transcription factors and/or with coregulator molecules contributeing to activation of PEPCK (show PEPCK Antibodies) gene.
These results indicate that Wwp2 plays an important role in regulating expression of Rpb1 in normal physiological conditions.[Rpb1]
weak, multivalent interactions between TAF15 fibrils and heptads throughout RNA pol II CTD collectively mediate complex formation.
This shows that CDK9 stimulates release of paused polymerase and activates transcription by increasing the number of transcribing polymerases and thus the amount of mRNA synthesized per time.
Results identified rs2071504 in POLR2A gene to be associated with poor overall and disease-free survival of patients with an early-stage non-small cell lung cancer.
Dara indicate that hydrogen peroxide alters RNA polymerase II (Pol II (show Pol II Antibodies)) occupancy at promoters and enhancers genome-wide.
Rpb1/2 dynamics help govern the decision between sense and divergent antisense transcription.
The results showed heterogeneity in the responses of individual KSHV episomes to stimuli within a single reactivating cell; those episomes that did respond to stimulation, aggregated within large domains that appear to function as viral transcription factories. A significant portion of cellular RNA polymerase II was trapped in these factories and served to transcribe viral genomes.
The authors show here that glutamine deprivation suppresses translation of endogenous MYC via coupling the 3'-UTR of the MYC mRNA and RNA polymerase II function.
Data show that inhibition of VCP/p97 (show vcp Antibodies), or siRNA-mediated ablation of VCP/p97 (show vcp Antibodies) impairs ultraviolet radiation (UVR)-induced RNA polymerase II (RNAPII (show Pol II Antibodies)) degradation.
Role of chromatin-bound EGFR and ERK kinases in RNA polymerase 2 transcription
recurrent somatic mutations in POLR2A hijack this essential enzyme and drive meningioma neoplasia
This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA.
DNA-directed RNA polymerase II subunit RPB1
, polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
, 220 kDa DNA-directed RNA polymerase polypeptide A
, DNA-directed RNA polymerase II largest subunit
, RNA polymerase II polypeptide A
, DNA-directed RNA polymerase II A
, DNA-directed RNA polymerase II subunit A
, DNA-directed RNA polymerase III largest subunit
, RNA polymerase II 1
, RNA polymerase II subunit B1
, Polymerase (RNA II (DNA directed), large polypeptide
, DNA-directed RNA polymerase II largest subunit, RNA polymerase II 220 kd subunit
, RNA-directed RNA polymerase II subunit RPB1
, polymerase (RNA) II (DNA directed) polypeptide A (220kD)