ROC1 Antibodies
(ROC1)
This locus encodes a RING finger-like domain-containing protein. The encoded protein interacts with cullin proteins and likely plays a role in ubiquitination processes necessary for cell cycle progression. This protein may also affect protein turnover. Related pseudogenes exist on chromosomes 2 and 5.[provided by RefSeq, Sep 2010].
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Recommended ROC1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC (fp)
Validations
Cat. No.
ABIN7454558
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
IHC
Validations
Cat. No.
ABIN2353135
Quantity
250 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IP
Validations
Cat. No.
ABIN2353131
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our ROC1 products
: "Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation." in: Cell, Vol. 134, Issue 6, pp. 995-1006, (2008) (PubMed).: "Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase." in: Science (New York, N.Y.), Vol. 284, Issue 5414, pp. 657-61, (1999) (PubMed).
: "ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity." in: Molecular cell, Vol. 3, Issue 4, pp. 535-41, (1999) (PubMed).
: "Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34." in: Genes & development, Vol. 13, Issue 12, pp. 1614-26, (1999) (PubMed).
Synonyms and alternative names related to ROC1
ring-box 1 (RBX1), BA554C12.1, RNF75, ROC1Protein level used designations for ROC1
- E3 ubiquitin-protein ligase RBX1
- RING box protein 1
- RING finger protein 75
- RING-box protein 1
- ZYP protein
- regulator of cullins 1
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