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anti-Human SHC3 Antibodies:
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Human Polyclonal SHC3 Primary Antibody for WB - ABIN2801960
Liu, Meakin: ShcB and ShcC activation by the Trk family of receptor tyrosine kinases. in The Journal of biological chemistry 2002
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Human Monoclonal SHC3 Primary Antibody for IF, IP - ABIN968083
Conti, Sipione, Magrassi, Bonfanti, Rigamonti, Pettirossi, Peschanski, Haddad, Pelicci, Milanesi, Pelicci, Cattaneo: Shc signaling in differentiating neural progenitor cells. in Nature neuroscience 2001
Show all 3 Pubmed References
Human Monoclonal SHC3 Primary Antibody for IF, IP - ABIN968082
OBryan, Songyang, Cantley, Der, Pawson: A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain. in Proceedings of the National Academy of Sciences of the United States of America 1996
Show all 3 Pubmed References
High SHC3 expression is associated with glioblastoma.
Rai (ShcC/N-Shc), a member of the family of Shc (show SHC1 Antibodies)-like adaptor proteins, as a new regulator of migration of normal and cancer stem/progenitor cells.
Polymorphism in RAI (show RNH1 Antibodies) and CD3EAP (show CD3EAP Antibodies) are associated with outcome of myeloma patients treated with high dose treatment.
amplification of SHC3 and EDG3 (show S1PR3 Antibodies) genes suggests that the two proteins co-operate and are important for ependymomas in vivo.
Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc (show SHC1 Antibodies).
ALK-ShcC signal activation, possibly caused by co-amplification with the N-myc gene, might give additional effects on malignant tumor progression of neuroblastoma.ShcC is a potent substrate of the activated ALK kinase.
The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret (show RET Antibodies) to the phosphatidylinositol 3-kinase/Akt (show AKT1 Antibodies) signaling pathway.
ShcC has phosphotyrosine-dependent and -independent functions in neuroblastoma (show ARHGEF16 Antibodies) cells
The inappropriate in vivo expression of Shc3 in high-grade glioma may contribute to the survival of the cancer cells.
data suggest that RAI (ShcC/H-Shc (show SHC1 Antibodies))is a critical substrate for RET (show RET Antibodies) oncoproteins in thyroid carcinomas
The results provide evidence that Rai/ShcC plays opposite roles in Th17 cell differentiation and astrocyte activation
Rai interferes with the TCR signaling cascade one of the earliest steps--recruitment of the initiating kinase ZAP-70 (show ZAP70 Antibodies) to the phosphorylated subunit of the TCR/CD3 (show CD3E Antibodies) complex.
TrkB (show NTRK2 Antibodies)-mediated ERK1/2 activation is impaired in huntingtin (show HTT Antibodies) knock-in striatal cells involves reduced p52 (show GTF2H4 Antibodies)/p46 (show POLDIP3 Antibodies) Shc (show SHC1 Antibodies) expression
binds the Trk (show NTRK1 Antibodies) receptors in a phosphotyrosine-dependent manner via their N-terminal phosphotyrosine binding domain
Rai has a functional neuroprotective role in brain injury, with possible implications in the treatment of stroke
ShcC mediates TrkB (show NTRK2 Antibodies)-Ras/MAPK (show MAPK1 Antibodies) signaling & regulates NMDA receptor function in the hippocampus via interaction with phosphotyrosines on the receptor subunits. It serves as a modulator of hippocampal synaptic plasticity underlying learning & memory.
Expressed in T and B cells; loss of Rai results in breaking of immunological tolerance and development of systemic autoimmunity.
may be involved in brain-derived neurotrophic factor signalling during retinal development
SH2 domain protein C3
, SHC-transforming protein 3
, SHC-transforming protein C
, neuronal Shc
, protein Rai
, src homology 2 domain-containing transforming protein C3
, src homology 2 domain-containing-transforming protein C3