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Study identified the Gas6 (show GAS6 Proteins)/TAM (show CCNA1 Proteins) receptor pathway with Tyro3 and Mer (show MERTK Proteins) as novel targets in colorectal cancer.
These results show that TYRO3, AXL (show AXL Proteins) and GAS6 (show GAS6 Proteins) are expressed at higher levels in LMS and expression of its ligands correlates to a worse PFS in LMS patients.
Patients with macroalbuminuria diabetes had higher circulating levels of sMer and more urinary soluble Tyro3 and sMer than normoalbuminuric diabetics. Increased clearance of sTyro3 and sMer was associated with loss of tubular Tyro3 and Mer (show MERTK Proteins) expression in diabetic nephropathy tissue. During in vitro diabetes, human kidney cells had down-regulation of Tyro3 and Mer (show MERTK Proteins) mRNA and increased shedding of sTyro3 and sMer.
TYRO3 is overexpressed in the early stage of colon cancer development and aberrant expression of TYRO3 promotes tumorigenesis and induces EMT (show ITK Proteins) through the regulation of SNAI1 (show SNAI1 Proteins).
In this paper, we review the biology of the Gas6 (show GAS6 Proteins)/Tyro3, Axl (show AXL Proteins), and MerTK (show MERTK Proteins)(collectively named TAM (show CCNA1 Proteins) system)and the current evidence supporting its potential role in the pathogenesis of multiple sclerosis .
these data suggest that Tyro3 contributes significantly to tumor growth, aggressiveness and liver dysfunction
Tyro3 gene dosage modulates Mertk (show MERTK Proteins)-associated retinal degeneration, provide strong evidence for a direct role for TYRO3 in RPE (show RPE Proteins) phagocytosis, and suggest that an eQTL (show EQTN Proteins) can modify a recessive Inherited photoreceptor degenerations.
The mRNA expression levels of Tyro-3, Axl (show AXL Proteins) were decreased in pSS (show CDSN Proteins) patients. When considering the plasma level, increased levels of soluble Mer (show MERTK Proteins) was observed with statistically significant difference.
genetic ablation of a receptor tyrosine kinase (show RET Proteins) encoded byTyro3in mice or the functional neutralization of its ortholog in human dendritic cells resulted in enhanced type 2 immunity.
the results of the present study demonstrated that the acquired taxol resistance of ovarian cancer cells was associated with ROS (show ROS1 Proteins)-dependent upregulation in the expression of Tyro3 RTK and the subsequent activation of Akt (show AKT1 Proteins).
The findings of this study indicated the critical importance of Tyro3 in potentiating central nervous system myelination
This study mapped the autophosphorylation sites of murine Tyro3 to tyrosine 723 and 756, with K540 being required for its kinase activity.
Axl (show AXL Proteins), Mertk (show MERTK Proteins) and Tyro3 receptors are not required for Zika virus entry and infection.
genetic ablation of a receptor tyrosine kinase (show ERBB3 Proteins) encoded byTyro3in mice or the functional neutralization of its ortholog in human dendritic cells resulted in enhanced type 2 immunity.
These results suggest that TAM (show CCNA1 Proteins) receptors support NSCs survival, proliferation and differentiation by regulating expression of neurotrophins, especially the nerve growth factor.
Optimal TAM (show CCNA1 Proteins) signaling requires coincident TAM (show CCNA1 Proteins) ligand engagement of both its receptor and the phospholipid phosphatidylserine regulating TAM (show CCNA1 Proteins) receptor tyrosine kinases Tyro3, Axl (show AXL Proteins), and Mer (show ERH Proteins) and their ligands Gas6 (show GAS6 Proteins) and Protein S.
These findings indicate that Tyro3 is a critical signal for synovial hyperplasia, osteoclast differentiation and bone erosion during arthritis.
Axl (show AXL Proteins) and Mer (show ERH Proteins) (TAM (show CCNA1 Proteins)) receptor tyrosine kinases (RTKs) developed persistent inflammatory liver damage resembling AIH. Tyro3(-/-)Axl (show AXL Proteins)(-/-)Mer (show ERH Proteins)(-/-) triple mutant (TAM (show CCNA1 Proteins)(-/-)) mice exhibited chronic hepatitis
Adult brain neurogenesis is reduced in the hippocampus of the Tyro3-/-Axl (show AXL Proteins)-/-Mertk (show MERTK Proteins)-/- triple-knockout but not in single Tyro3-/- knockouts.
The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses.
TYRO3 protein tyrosine kinase
, Tyrosine-protein kinase receptor TYRO3
, tyrosine-protein kinase receptor TYRO3
, developmental receptor tyrosine kinase
, tyrosine-protein kinase DTK
, tyrosine-protein kinase receptor TYRO3-like
, tyrosine-protein kinase RSE
, tyrosine-protein kinase SKY
, tyrosine-protein kinase TIF
, tyrosine-protein kinase byk
, Bruton agammaglobulinemia tyrosine kinase
, TYRO3 protein tyrosine kinase 3
, Axl-related receptor tyrosine kinase
, protein-tyrosine kinase
, retina-expressed kinase
, Xenopus kinase of Sky family
, tyrosine kinase