TYRO3 Protein (AA 41-427) (His tag)

Catalog No. ABIN7275812

Product Details

Target: TYRO3 (TYRO3 Protein Tyrosine Kinase (TYRO3))

Protein Type: Recombinant

Protein Characteristics: AA 41-427

Origin: Cynomolgus

Source: HEK-293 Cells

Purification tag / Conjugate: This TYRO3 protein is labelled with His tag.

Purpose: Cynomolgus TYRO3 Protein

Sequence: Gly41-Ser427

Characteristics: Recombinant Cynomolgus TYRO3 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gly41-Ser427.

Purity: > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by SEC-HPLC

Sterility: 0.22 μm filtered

Endotoxin Level: Less than 1EU per μg by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.

Buffer: Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.

Storage: -20 °C,-80 °C

Storage Comment: -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: TYRO3 (TYRO3 Protein Tyrosine Kinase (TYRO3))

Alternative Name: TYRO3 (TYRO3 Products)

Synonyms: TYRO3 Protein, brt Protein, byk Protein, dtk Protein, rse Protein, sky Protein, tif Protein, Xksy Protein, MGC145734 Protein, DKFZp469I0432 Protein, LOC100231598 Protein, BYK Protein, Dtk Protein, RSE Protein, Sky Protein, Tif Protein, Brt Protein, REK Protein, ksy Protein, xksy Protein, AI323366 Protein, Etk-2 Protein, Rse Protein, TYRO3 protein tyrosine kinase Protein, TYRO3 protein tyrosine kinase L homeolog Protein, TYRO3 protein tyrosine kinase 3 Protein, TYRO3 Protein, tyro3 Protein, Tyro3 Protein, tyro3.L Protein

Background: The TAM receptors (Tyro3, Axl and MerTK) are promising therapeutic targets on tumor-associated macrophages. The TAM receptors are a family of receptor tyrosine kinases with shared ligands Gas6 and Protein S that skew macrophage polarization towards a pro-tumor M2-like phenotype.In macrophages, the TAM receptors also promote apoptotic cell clearance, a tumor-promoting process called efferocytosis. The TAM receptors bind the "eat-me" signal phosphatidylserine on apoptotic cell membranes using Gas6 and Protein S as bridging ligands.

Molecular Weight: 42.47 kDa. Due to glycosylation, the protein migrates to 50-70 kDa based on Tris-Bis PAGE result.

UniProt: A0A2K5WCY8

Pathways: RTK Signaling