Mouse anti-Human Immunoglobulin kappa Chain Complex (Igk) (Light Chain) Antibody (CF®488A)

Catalog No. ABIN7879479

Quick Overview for Mouse anti-Human Immunoglobulin kappa Chain Complex (Igk) (Light Chain) Antibody (CF®488A) (ABIN7879479)

Target: Igk (Immunoglobulin kappa Chain Complex (Igk))

Clonality: Monoclonal

Conjugate: CF®488A

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: KLC709

Isotype: IgG1, kappa

Product Details

Binding Specificity: Light Chain

Reactivity: Human

Host: Mouse

Purpose: Kappa Light Chain Antibody

Purification: Protein G affinity chromatography

Immunogen: Recombinant human Kappa light chain was used as the immunogen for this Kappa light chain antibody.

Application Details

Application Notes: Optimal dilution of the Kappa Light Chain antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 500 µL at 0.1 mg/mL with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the Kappa Light Chain antibody at 2-8oC, protected from light.

Target Details

Target: Igk (Immunoglobulin kappa Chain Complex (Igk))

Alternative Name: Kappa

Background: This antibody is specific to the kappa light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. In general, the ratio of Kappa to Lambda is 3:1. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the kappa light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.