TAF1 Products
(TAF1 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 250kDa (TAF1))
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Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. This gene is part of a complex transcriptional unit (TAF1/DYT3), wherein some products share exons with TAF1 as well as additional exons downstream.[provided by RefSeq, Aug 2009].
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Featured TAF1 Categories
TAF1 Antibodies
High quality antibodies with extensive validation data.
TAF1 ELISA Kits
Reliable ELISA kits for a wide range of species.
TAF1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended TAF1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (1)
- (4)
Cat. No.
ABIN233826
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Cow, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat
Application
WB, IHC, ChIP
Validations
- (4)
Cat. No.
ABIN2779667
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, IF, ICC
Validations
- (2)
Cat. No.
ABIN6265434
Quantity
100 μL
Datasheet
Datasheet
Recommended TAF1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN5594421
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1162526
Quantity
96 tests
Datasheet
Datasheet
Recommended TAF1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7125310
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7125311
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7125309
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our TAF1 products
: "The general transcription factor TAF7 is essential for embryonic development but not essential for the survival or differentiation of mature T cells." in: Molecular and cellular biology, Vol. 32, Issue 10, pp. 1984-97, (2012) (PubMed).: "Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a role for TAF1 in cell G1 progression." in: Molecular cell, Vol. 13, Issue 6, pp. 867-78, (2004) (PubMed).
: "Taf(II) 250 phosphorylates human transcription factor IIA on serine residues important for TBP binding and transcription activity." in: The Journal of biological chemistry, Vol. 276, Issue 19, pp. 15886-92, (2001) (PubMed).
: "Structure and function of a human TAFII250 double bromodomain module." in: Science (New York, N.Y.), Vol. 288, Issue 5470, pp. 1422-5, (2000) (PubMed).
Synonyms and alternative names related to TAF1
TBP-associated factor 1 (Taf1), TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa (TAF1), transcription initiation factor TFIID subunit 1 (LOC5567420), transcription initiation factor TFIID subunit 1 (CpipJ_CPIJ003658), transcription initiation factor TFIID subunit 1 (TAF11.1), transcription initiation factor TFIID, subunit TAF1 (HAF1501), transcription initiation factor TFIID, subunit TAF1 (HAF1502), TATA-box binding protein associated factor 1 (TAF1), transcription initiation factor TFIID subunit 1 (LOC100457071), TATA-box binding protein associated factor 1 (Taf1), 250kDa, AU015687, B430306D02Rik, BA2R, BG:DS00004.13, Ccg-1, Ccg1, CCG1, CCGS, cel, cell, CG17603, d230, Dmel\\CG17603, dmTAF1, dmTAF[[II]]230, dTAF230, dTAF250, dTAFII250, dTAF[[II]]230, dTAF[[II]]250, DYT3, DYT3/TAF1, EfW1, KAT4, l(3)84Ab, N-TAF1, NSCL2, OF, p230, P250, p250, RGD1562050, SR3-5, TAF, TAF(II)250, TAF1, Taf1p, Taf2a, TAF2A, TAF200, Taf200, TAF230, Taf230, TAF250, Taf250, TAF250/230, TAFII-250, TAFII250, TAF[II]250, TAF[[II]], TAF[[II]]230, TAF[[II]]250, Taf[[II]]250, TAF[[II]]250/230, TFIID, TFIID TAF250, XDPProtein level used designations for TAF1
- CG17603-PA
- CG17603-PB
- CG17603-PC
- CG17603-PD
- CG17603-PE
- TATA-associated factor 250
- TBP-associated factor
- TBP-associated factor 250
- TBP-associated factor 250kD
- TFIID 230 kda subunit
- Taf1-PA
- Taf1-PB
- Taf1-PC
- Taf1-PD
- Taf1-PE
- cell lethal
- suppressor of Ras85D 3-5
- TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
- transcription initiation factor TFIID subunit 1
- transcription initiation factor TFIID, subunit TAF1
- TBP-associated factor 1-like
- transcription initiation factor TFIID subunit 1-like
- TAF(II)250
- TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, neuron specific isoform
- TAFII-250
- TBP-associated factor 250 kDa
- cell cycle gene 1 protein
- cell cycle, G1 phase defect
- p250
- transcription initiation factor TFIID 250 kDa subunit
- complementation of cell cycle block, G1-to-S
- transcription factor TFIID p250 polypeptide
- Cell cycle gene 1 protein
- Transcription initiation factor TFIID 250 kDa subunit
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