Protein Summary

The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts.

Alternative names and synonyms associated with TAB2

• TGF-beta activated kinase 1/MAP3K7 binding protein 2 (TAB2) antibody
• TGF-beta activated kinase 1/MAP3K7 binding protein 2 (Tab2) antibody
• TGF-beta activated kinase 1/MAP3K7 binding protein 2 (tab2) antibody

• 1110030N06Rik antibody
• A530078N03Rik antibody
• CHTD2 antibody
• map3k7ip2 antibody
• mKIAA0733 antibody
• Show all synonym aliases
• zgc:77446 antibody

Protein level used designations for TAB2

TGF-beta activated kinase 1/MAP3K7 binding protein 2 , mitogen-activated protein kinase kinase kinase 7-interacting protein 2-like , TAB-2 , TAK1-binding protein 2 , TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 , TGF-beta-activated kinase 1-binding protein 2 , mitogen-activated protein kinase kinase kinase 7-interacting protein 2 , mitogen-activated protein kinase kinase kinase 7 interacting protein 2 , Tak1 binding protein 2 , mitogen activated protein kinase kinase kinase 7 interacting protein 2 , mitogen-activated protein kinase kinase kinase 7-interacting protein 2 homolog