Browse our anti-TAB2 (TAB2) Antibodies

Human TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2) interaction partners

1. Data indicate an association between TAK1-binding protein 2 (TAB2) mutations and a connective tissue disorder with severe polyvalvular heart disease and subtle facial dysmorphism.

2. The combination of WES, genomic triangulation, and systems biology has uncovered perturbations in TGF-beta activated kinase 1 (show MAP3K7 Antibodies) signaling as a novel pathogenic substrate for polyvalvular syndrome.

3. Data suggest that mRNA/protein levels of NLRP6 (show NLRP6 Antibodies) are down-regulated in synovial tissues and synoviocytes of rheumatoid arthritis (RA) patients compared to osteoarthritis patients; NLRP6 (show NLRP6 Antibodies) provides docking site to facilitate interaction between TAB2/3 and TRIM38 (show TRIM38 Antibodies) in RA synoviocytes in response to TNFalpha (show TNF Antibodies). (NLRP6 (show NLRP6 Antibodies) = ; TAB2/3 = transforming growth factor-b (show ATP5S Antibodies)-activated kinase 1-binding protein 2/3; TRIM38 (show TRIM38 Antibodies) = tripartite motif 38)

4. A Novel Functional Domain of Tab2 Involved in the Interaction with Estrogen Receptor Alpha (show ESR1 Antibodies) in Breast Cancer Cells

5. The expression of miR (show MLXIP Antibodies)-155 target gene, TAB2, and the downstream gene, iNOS (show NOS2 Antibodies), were found to be inhibited in psoriatic dermal mesenchymal stem cells.

6. DK1 (show DOLK Antibodies) inhibits the formation of the TAK1 (show MAP3K7 Antibodies)-TAB2-TRAF6 (show TRAF6 Antibodies) complex and leads to the inhibition of TRAF6 (show TRAF6 Antibodies) ubiquitination.

7. Authors demonstrate that enterovirus 71 3C interacts with TAB2 and TAK1 (show MAP3K7 Antibodies) and suppresses cytokine expression via cleavage of the TAK1 (show MAP3K7 Antibodies) complex proteins.

8. SUMOylation may serve as a novel mechanism for the regulation of TAB2.

9. conclude that TRIM38 (show TRIM38 Antibodies) negatively regulates TNFalpha (show TNF Antibodies)- and IL-1beta (show IL1B Antibodies)-induced signaling by mediating lysosome-dependent degradation of TAB2/3, two critical components in TNFalpha (show TNF Antibodies)- and IL-1beta (show IL1B Antibodies)-induced signaling pathways

10. These data indicate that overexpression of TRIM22 (show TRIM22 Antibodies) may negatively regulate the TRAF6 (show TRAF6 Antibodies)-stimulated NF-kappaB (show NFKB1 Antibodies) pathway by interacting with and degrading TAB2.

Mouse (Murine) TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2) interaction partners

1. These findings support a regulatory role for TGF-beta-activated kinase 1 (show MAP3K7 Antibodies) in governing downstream MAPKs/NF-kappaB (show NFKB1 Antibodies) signaling cascades in the macrophage activation in response to hyperglycemic insult

2. RNF4 (show RNF4 Antibodies) negatively regulates NF-kappaB (show NFKB1 Antibodies) signaling by down-regulating TAB2

3. TAB1 (show TAB1 Antibodies) and TAB2 are required for activated macrophages, making TAB1 (show TAB1 Antibodies) and TAB2 effective targets to control inflammation by modulating macrophage survival.

4. Loss of Tab2 is associated with liver injury.

5. miR (show MLXIP Antibodies)-155 inhibits the immunosuppressive capacity of MSCs by reducing iNOS (show NOS2 Antibodies) expression by targeting TAB2.

6. TAB2 and TAB3 (show TAB3 Antibodies) are essential for B cell activation (show BLNK Antibodies) leading to antigen-specific antibody responses, as well as B-1 and marginal zone B cell development.

7. We found that endothelial TAK1 (show NR2C2 Antibodies) and TAB2, but not TAB1 (show TAB1 Antibodies), were critically involved in vascular formation

8. MiR (show MLXIP Antibodies)-23b suppresses IL-17 (show IL17A Antibodies)-, tumor necrosis factor alpha (TNF-alpha (show TNF Antibodies))- or IL-1beta (show IL1B Antibodies)-induced NF-kappaB (show NFKB1 Antibodies) activation and inflammatory cytokine expression by targeting TAB2, TAB3 (show TAB3 Antibodies) and IKK-alpha (show CHUK Antibodies).

9. Epithelial TAK1 (show NR2C2 Antibodies) activity is regulated through two unique, TAB1 (show TAB1 Antibodies)-dependent basal & TAB2-mediated stimuli-dependent mechanisms.

10. TAK1 (show NR2C2 Antibodies) and its adapter protein (show GRB10 Antibodies), TAB2, reciprocally regulate both TAK1 (show NR2C2 Antibodies)- and ASK1 (show MAP3K5 Antibodies)-mediated signaling pathways to direct the activations of NF-kappaB (show NFKB1 Antibodies) and AP-1 (show JUN Antibodies).

Zebrafish TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2) interaction partners

1. a critical, dosage-sensitive role during development was demonstrated by the cardiac defects observed upon titrated knockdown of tab2 expression in zebrafish embryos